SMER 3
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- $81 - $1500
- Product name: SMER 3
- CAS: 67200-34-4
- MF: C11H4N4O2
- MW: 224.18
- EINECS:
- MDL Number:MFCD00451458
- Synonyms:SMER 3;9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one;9H-indeno[2,1-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one;OC1181, 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one;SMER3(SMER 3);9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one N;5-oxoinden[1,2-e]furazano[3,4-b]pyrazine;Ubiquitin activating enzyme,SMER-3,SCF,E1/E2/E3 Enzyme,SMER3,anticancer,MET,Skp1,E1 activating enzyme,ligase,Inhibitor,Cullin,E2 conjugating enzyme,ubiquitin,Ubiquitin conjugating enzyme,Ubiquitin ligase,E3 ligating enzyme,inhibit
19 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Cayman Chemical
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10
- 5MG
- 50
- 10MG
- 2x10mg
- 25MG
- 50mg
- 2x50mg
- 1g
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001231
- Product descriptionSMER3 95.00%
- Packaging5MG
- Price$479.5
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001231
- Product descriptionSMER3 95.00%
- Packaging10MG
- Price$559
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001231
- Product descriptionSMER3 95.00%
- Packaging25MG
- Price$797.5
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5567
- Product descriptionSMER3
- Packaging10mg
- Price$282
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5567
- Product descriptionSMER3
- Packaging50mg
- Price$1190
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1904
- Product descriptionSMER3 99%
- Packaging2x10mg
- Price$154
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1904
- Product descriptionSMER3 99%
- Packaging2x50mg
- Price$440
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15324
- Product descriptionSMER3 ≥95%
- Packaging5mg
- Price$81
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15324
- Product descriptionSMER3 ≥95%
- Packaging10mg
- Price$120
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15324
- Product descriptionSMER3 ≥95%
- Packaging25mg
- Price$199
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15324
- Product descriptionSMER3 ≥95%
- Packaging50mg
- Price$427
- Updated2024-03-01
- Buy
- ManufacturerDC Chemicals
- Product numberDC7895
- Product descriptionSMER3(SMER3) >98%
- Packaging1g
- Price$1500
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number72342
- Product descriptionSMER3
- Packaging10mg
- Price$625
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberS7826
- Product descriptionSMER3 ≥98% (HPLC)
- Packaging5mg
- Price$113
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberS7826
- Product descriptionSMER3 ≥98% (HPLC)
- Packaging25mg
- Price$436
- Updated2024-03-01
- Buy
- ManufacturerTocris
- Product number4375
- Product descriptionSMER3 ≥98%(HPLC)
- Packaging10
- Price$191
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | INB0001231 | SMER3 95.00% | 5MG | $479.5 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001231 | SMER3 95.00% | 10MG | $559 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001231 | SMER3 95.00% | 25MG | $797.5 | 2021-12-16 | Buy |
| ApexBio Technology | B5567 | SMER3 | 10mg | $282 | 2021-12-16 | Buy |
| ApexBio Technology | B5567 | SMER3 | 50mg | $1190 | 2021-12-16 | Buy |
| Axon Medchem | Axon1904 | SMER3 99% | 2x10mg | $154 | 2021-12-16 | Buy |
| Axon Medchem | Axon1904 | SMER3 99% | 2x50mg | $440 | 2021-12-16 | Buy |
| Cayman Chemical | 15324 | SMER3 ≥95% | 5mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 15324 | SMER3 ≥95% | 10mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 15324 | SMER3 ≥95% | 25mg | $199 | 2024-03-01 | Buy |
| Cayman Chemical | 15324 | SMER3 ≥95% | 50mg | $427 | 2024-03-01 | Buy |
| DC Chemicals | DC7895 | SMER3(SMER3) >98% | 1g | $1500 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 72342 | SMER3 | 10mg | $625 | 2021-12-16 | Buy |
| Sigma-Aldrich | S7826 | SMER3 ≥98% (HPLC) | 5mg | $113 | 2024-03-01 | Buy |
| Sigma-Aldrich | S7826 | SMER3 ≥98% (HPLC) | 25mg | $436 | 2024-03-01 | Buy |
| Tocris | 4375 | SMER3 ≥98%(HPLC) | 10 | $191 | 2021-12-16 | Buy |
Properties
Melting point :283-284 °C(Solv: ethanol (64-17-5))
Boiling point :437.2±55.0 °C(Predicted)
Density :1.665±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥30mg/mL
pka :-8.15±0.20(Predicted)
form :powder
color :yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Boiling point :437.2±55.0 °C(Predicted)
Density :1.665±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥30mg/mL
pka :-8.15±0.20(Predicted)
form :powder
color :yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
SMER3 is a selective inhibitor of Skp1-Cullin-F-box (SCF)MET30 ubiquitin ligase, an E3 ligase that regulates transcription, cell-cycle control, and immune response. It is a small molecule enhancer of rapamycin , in that it enhances yeast cell lethality in response to rapamycin. SMER3, at 5 μM, upregulates a set of methionine biosynthesis genes by altering the SCFMET30 complex, preventing ubiquitination of target proteins, including Met4. As ubiquitin E3 ligases are involved in tumorigenesis, SMER3 has potential applications in cancer research.Related product price
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