SR 1001
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- $32 - $795
- Product name: SR 1001
- CAS: 1335106-03-0
- MF: C15H13F6N3O4S2
- MW: 477.4
- EINECS:
- MDL Number:MFCD23160036
- Synonyms:SR 1001;SR1001,N-{4-Methyl-5-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoroMethyl-ethyl)-phenylsulfaMoyl]-thiazol-2-yl}-acetaMide;N-(5-(N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)sulphamoyl)-4-methylthiazol-2-yl)acetamide;N-(5-{[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxy-2-propanyl)phenyl]sulfamoyl}-4-methyl-1,3-thiazol-2-yl)acetamide;N-[4-Methyl-5-[[[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]sulfonyl]-2-thiazolylacetamide;SR-1001;SR 1001;Acetamide, N-[4-methyl-5-[[[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]sulfonyl]-2-thiazolyl]-;SR1001 >=98% (HPLC)
20 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- ApexBio Technology
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- ManufacturerAK Scientific
- Product number4062AH
- Product descriptionSR1001
- Packaging25mg
- Price$477
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA240693
- Product descriptionSR-1001 98+%
- Packaging5mg
- Price$114
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA240693
- Product descriptionSR-1001 98+%
- Packaging10mg
- Price$196
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA240693
- Product descriptionSR-1001 98+%
- Packaging50mg
- Price$332
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5742
- Product descriptionSR1001
- Packaging10mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5742
- Product descriptionSR1001
- Packaging50mg
- Price$620
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number10922
- Product descriptionSR 1001 ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10922
- Product descriptionSR 1001 ≥98%
- Packaging5mg
- Price$106
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10922
- Product descriptionSR 1001 ≥98%
- Packaging10mg
- Price$186
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10922
- Product descriptionSR 1001 ≥98%
- Packaging25mg
- Price$404
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-3963
- Product descriptionSR1001 99.84%
- Packaging5mg
- Price$96
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3963
- Product descriptionSR1001 99.84%
- Packaging10mg
- Price$180
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3963
- Product descriptionSR1001 99.84%
- Packaging50mg
- Price$744
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003847
- Product descriptionSR1001 98+%
- Packaging5mg
- Price$63
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003847
- Product descriptionSR1001 98+%
- Packaging10mg
- Price$105
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003847
- Product descriptionSR1001 98+%
- Packaging50mg
- Price$434
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 4062AH | SR1001 | 25mg | $477 | 2021-12-16 | Buy |
| Ambeed | A240693 | SR-1001 98+% | 5mg | $114 | 2021-12-16 | Buy |
| Ambeed | A240693 | SR-1001 98+% | 10mg | $196 | 2021-12-16 | Buy |
| Ambeed | A240693 | SR-1001 98+% | 50mg | $332 | 2021-12-16 | Buy |
| ApexBio Technology | B5742 | SR1001 | 10mg | $150 | 2021-12-16 | Buy |
| ApexBio Technology | B5742 | SR1001 | 50mg | $620 | 2021-12-16 | Buy |
| Cayman Chemical | 10922 | SR 1001 ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 10922 | SR 1001 ≥98% | 5mg | $106 | 2024-03-01 | Buy |
| Cayman Chemical | 10922 | SR 1001 ≥98% | 10mg | $186 | 2024-03-01 | Buy |
| Cayman Chemical | 10922 | SR 1001 ≥98% | 25mg | $404 | 2024-03-01 | Buy |
| ChemScene | CS-3963 | SR1001 99.84% | 5mg | $96 | 2021-12-16 | Buy |
| ChemScene | CS-3963 | SR1001 99.84% | 10mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-3963 | SR1001 99.84% | 50mg | $744 | 2021-12-16 | Buy |
| Crysdot | CD31003847 | SR1001 98+% | 5mg | $63 | 2021-12-16 | Buy |
| Crysdot | CD31003847 | SR1001 98+% | 10mg | $105 | 2021-12-16 | Buy |
| Crysdot | CD31003847 | SR1001 98+% | 50mg | $434 | 2021-12-16 | Buy |
Properties
Density :1.640±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: >5mg/mL
pka :5.90±0.50(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Protect from moisture. Solutions in DMSO may be stored at -20° for up to 3 months.
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: >5mg/mL
pka :5.90±0.50(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Protect from moisture. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
Retinoic-acid-receptor-related orphan receptors (ROR) α and γ play a key role in the development of T-helper cells that produce interleukin-17 (TH17 cells), a subset of CD4+ T-cells that contribute to the inflammatory process and have been implicated in the pathology of autoimmune diseases. SR 1001 is a synthetic ligand specific for RORα and RORγ (Kis = 172 and 111 nM, respectively) that functions as an inverse agonist at these receptors. SR 1001 has been shown to suppress IL-17 promoter driven transcriptional activity by inhibiting the interaction of co-activators such as TRAP220 nuclear receptor box 2 peptide (IC50 = 117 nM) and SRC2 with RORα and RORγ as well as by increasing the recruitment of corepressors such as NCoR. At 5 μM, SR 1001 inhibits TH17 cell differentiation and IL-17A secretion in cultured splenocytes and human PBMCs. A 25 mg/kg dose of SR 1001 twice/day delays the onset and the severity of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis.Related product price
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