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ChemicalBook >> CAS DataBase List >> Smad3 Inhibitor, SIS3

Smad3 Inhibitor, SIS3

Smad3 Inhibitor, SIS3 price.
  • $65 - $877.28
  • Product name: Smad3 Inhibitor, SIS3
  • CAS: 1009104-85-1
  • MF: C28H27N3O3
  • MW: 453.53
  • EINECS:-0
  • MDL Number:MFCD24368989
  • Synonyms:Smad3 Inhibitor;Smad3 Inhibitor, SIS3;SIS3 free base;SMAD3 Inhibtor, SIS 3;(E)-1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-3-pyrrolo[2,3-b]pyridyl)-2-propen-1-one;2-Propen-1-one, 1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-;SIS-3 free base,SIS3 free base;1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one
9 prices
Selected condition:
Brand
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • Medical Isotopes, Inc.
  • TRC
  • Usbiological
Package
  • 500μg
  • 1mg
  • 2.5mg
  • 5MG
  • 25mg
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000052
  • Product descriptionSIS-3 95.00%
  • Packaging5MG
  • Price$877.28
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number15945
  • Product descriptionSMAD3 Inhibitor, SIS3 ≥98%
  • Packaging500μg
  • Price$65
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15945
  • Product descriptionSMAD3 Inhibitor, SIS3 ≥98%
  • Packaging1mg
  • Price$121
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15945
  • Product descriptionSMAD3 Inhibitor, SIS3 ≥98%
  • Packaging5mg
  • Price$380
  • Updated2024-03-01
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number48688
  • Product descriptionSMAD3Inhibtor,SIS3
  • Packaging5mg
  • Price$695
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberS564500
  • Product descriptionSMAD3Inhibtor,SIS3
  • Packaging2.5mg
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberS564500
  • Product descriptionSMAD3Inhibtor,SIS3
  • Packaging5mg
  • Price$205
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberS564500
  • Product descriptionSMAD3Inhibtor,SIS3
  • Packaging25mg
  • Price$820
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number466177
  • Product descriptionSMAD3 Inhibtor, SIS 3
  • Packaging2.5mg
  • Price$425
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation INB0000052 SIS-3 95.00% 5MG $877.28 2021-12-16 Buy
Cayman Chemical 15945 SMAD3 Inhibitor, SIS3 ≥98% 500μg $65 2024-03-01 Buy
Cayman Chemical 15945 SMAD3 Inhibitor, SIS3 ≥98% 1mg $121 2024-03-01 Buy
Cayman Chemical 15945 SMAD3 Inhibitor, SIS3 ≥98% 5mg $380 2024-03-01 Buy
Medical Isotopes, Inc. 48688 SMAD3Inhibtor,SIS3 5mg $695 2021-12-16 Buy
TRC S564500 SMAD3Inhibtor,SIS3 2.5mg $130 2021-12-16 Buy
TRC S564500 SMAD3Inhibtor,SIS3 5mg $205 2021-12-16 Buy
TRC S564500 SMAD3Inhibtor,SIS3 25mg $820 2021-12-16 Buy
Usbiological 466177 SMAD3 Inhibtor, SIS 3 2.5mg $425 2021-12-16 Buy

Properties

storage temp. :Store at -20°C
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.2 mg/ml
form :A crystalline solid

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

SMAD3 is a receptor-regulated intracellular protein that functions downstream of TGF-β and activin receptors and mediates their signaling, playing a role in cell proliferation, differentiation, apoptosis and formation of extracellular matrix. SMAD3 Inhibitor, SIS3 selectively inhibits TGF-β and activin signaling by suppressing Smad3 phosphorylation (IC50 = 3 μM) without affecting the MAPK/p38, ERK, or PI3-kinase signaling pathways. It has been shown to reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.