Syk Inhibitor II
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- $80 - $1950
- Product name: Syk Inhibitor II
- CAS: 726695-51-8
- MF: C14H15F3N6O
- MW: 340.3
- EINECS:
- MDL Number:MFCD12922523
- Synonyms:ATP-competitive,Serotonin Receptor,antigen,inhibit,Spleen tyrosine kinase,Syk Inhibitor II,Anti-allergic,pyrimidine-carboxamide,Inhibitor,Syk,5-HT Receptor,5-hydroxytryptamine Receptor;5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-;2-((2-Aminoethyl)amino)-4-((3-(trifluoromethyl)phenyl)amino)pyrimidine-5-carboxamide
9 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- Cayman Chemical
- ChemScene
- DC Chemicals
Package
- 500μg
- 1mg
- 5MG
- 10mg
- 50mg
- 1g
- ManufacturerAK Scientific
- Product number9765CQ
- Product descriptionSykInhibitorII
- Packaging1mg
- Price$351
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001405
- Product description2-[(2-AMINOETHYL)AMINO]-4-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO]-5-PYRIMIDINECARBOXAMIDE 95.00%
- Packaging5MG
- Price$505.68
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18202
- Product descriptionSyk Inhibitor II ≥98%
- Packaging500μg
- Price$120
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18202
- Product descriptionSyk Inhibitor II ≥98%
- Packaging1mg
- Price$228
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18202
- Product descriptionSyk Inhibitor II ≥98%
- Packaging5mg
- Price$952
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0079263
- Product descriptionSykInhibitorII 98.05%
- Packaging5mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0079263
- Product descriptionSykInhibitorII 98.05%
- Packaging10mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0079263
- Product descriptionSykInhibitorII 98.05%
- Packaging50mg
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10900
- Product descriptionSykinhibitorII >98%
- Packaging1g
- Price$1950
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 9765CQ | SykInhibitorII | 1mg | $351 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001405 | 2-[(2-AMINOETHYL)AMINO]-4-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO]-5-PYRIMIDINECARBOXAMIDE 95.00% | 5MG | $505.68 | 2021-12-16 | Buy |
| Cayman Chemical | 18202 | Syk Inhibitor II ≥98% | 500μg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 18202 | Syk Inhibitor II ≥98% | 1mg | $228 | 2024-03-01 | Buy |
| Cayman Chemical | 18202 | Syk Inhibitor II ≥98% | 5mg | $952 | 2024-03-01 | Buy |
| ChemScene | CS-0079263 | SykInhibitorII 98.05% | 5mg | $80 | 2021-12-16 | Buy |
| ChemScene | CS-0079263 | SykInhibitorII 98.05% | 10mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-0079263 | SykInhibitorII 98.05% | 50mg | $400 | 2021-12-16 | Buy |
| DC Chemicals | DC10900 | SykinhibitorII >98% | 1g | $1950 | 2021-12-16 | Buy |
Properties
Melting point :270-272 °C (decomp)(Solv: water (7732-18-5); ethanol (64-17-5))
Boiling point :541.6±60.0 °C(Predicted)
Density :1.455±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 25 mg/ml; DMSO: 15 mg/ml
form :A crystalline solid
pka :14.04±0.50(Predicted)
color :White to off-white
Boiling point :541.6±60.0 °C(Predicted)
Density :1.455±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 25 mg/ml; DMSO: 15 mg/ml
form :A crystalline solid
pka :14.04±0.50(Predicted)
color :White to off-white
Safety Information
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| Signal word: | Warning | |||||||
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Description
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs and mediates downstream signaling. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner. It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 μM, respectively). Syk inhibitor II has been shown to prevent FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro (IC50 = 460 nM) and to inhibit passive cutaneous anaphylaxis reactions in mice (ID50 = 13.2 mg/kg, s.c.).Suppliers and manufacturers
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