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ChemicalBook >> CAS DataBase List >> TAPI-1

TAPI-1

TAPI-1 price.
  • $149 - $3200
  • Product name: TAPI-1
  • CAS: 171235-71-5
  • MF: C26H37N5O5
  • MW: 499.6
  • EINECS:
  • MDL Number:MFCD02684280
  • Synonyms:N1-((S)-1-((S)-1-(2-aminoethylamino)-1-oxopropan-2-ylamino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide;N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-L-alaninamide;N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-L-alaninamide TAPI-1;TAPI-1 trifluoroacetate;TNF-Α PROTEASE INHIBITOR-1 (TAPI-1);2-aminoethyl Amide;N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine;N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-NAPHTHYLALANYL-L-ALANINE; 2-AMINOETHYL AMIDE; TNF-Α PROTEASE INHIBITOR-1
13 prices
Selected condition:
Brand
  • ApexBio Technology
  • Biorbyt Ltd
  • Cayman Chemical
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Usbiological
Package
  • 10μg
  • 500μg
  • 1mg
  • 2.5mg
  • 5mg
  • 100ul
  • 10mM(in 1mL DMSO)
  • 100mg
  • 1g
  • ManufacturerApexBio Technology
  • Product numberB4686
  • Product descriptionTAPI-1
  • Packaging1mg
  • Price$189
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4686
  • Product descriptionTAPI-1
  • Packaging5mg
  • Price$662
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4686
  • Product descriptionTAPI-1
  • Packaging10mM(in 1mL DMSO)
  • Price$780
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb531217
  • Product descriptionTAP1
  • Packaging10μg
  • Price$1317.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18505
  • Product descriptionTAPI-1 ≥98%
  • Packaging500μg
  • Price$149
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18505
  • Product descriptionTAPI-1 ≥98%
  • Packaging1mg
  • Price$253
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18505
  • Product descriptionTAPI-1 ≥98%
  • Packaging5mg
  • Price$894
  • Updated2024-03-01
  • Buy
  • ManufacturerCrysdot
  • Product numberCD22004365
  • Product descriptionTAPI-1(RandomConfiguration) 97%
  • Packaging5mg
  • Price$463
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC7560
  • Product descriptionTAPI-1 >98%
  • Packaging100mg
  • Price$800
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC7560
  • Product descriptionTAPI-1 >98%
  • Packaging1g
  • Price$3200
  • Updated2021-12-16
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number53067
  • Product descriptionTAPI-1
  • Packaging2.5mg
  • Price$950
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number579051
  • Product descriptionTAPI-1 - CAS 171235-71-5 - Calbiochem
    TAPI-1, CAS 171235-71-5, is a structural analog of TAPI-0 with similar in vitro efficacy for the inhibition of MMPs and TACE. Blocks the shedding of several cell surface proteins.
  • Packaging1mg
  • Price$475
  • Updated2024-03-01
  • Buy
  • ManufacturerUsbiological
  • Product number493389
  • Product descriptionTAP1
  • Packaging100ul
  • Price$529
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ApexBio Technology B4686 TAPI-1 1mg $189 2021-12-16 Buy
ApexBio Technology B4686 TAPI-1 5mg $662 2021-12-16 Buy
ApexBio Technology B4686 TAPI-1 10mM(in 1mL DMSO) $780 2021-12-16 Buy
Biorbyt Ltd orb531217 TAP1 10μg $1317.5 2021-12-16 Buy
Cayman Chemical 18505 TAPI-1 ≥98% 500μg $149 2024-03-01 Buy
Cayman Chemical 18505 TAPI-1 ≥98% 1mg $253 2024-03-01 Buy
Cayman Chemical 18505 TAPI-1 ≥98% 5mg $894 2024-03-01 Buy
Crysdot CD22004365 TAPI-1(RandomConfiguration) 97% 5mg $463 2021-12-16 Buy
DC Chemicals DC7560 TAPI-1 >98% 100mg $800 2021-12-16 Buy
DC Chemicals DC7560 TAPI-1 >98% 1g $3200 2021-12-16 Buy
Medical Isotopes, Inc. 53067 TAPI-1 2.5mg $950 2021-12-16 Buy
Sigma-Aldrich 579051 TAPI-1 - CAS 171235-71-5 - Calbiochem
TAPI-1, CAS 171235-71-5, is a structural analog of TAPI-0 with similar in vitro efficacy for the inhibition of MMPs and TACE. Blocks the shedding of several cell surface proteins.
1mg $475 2024-03-01 Buy
Usbiological 493389 TAP1 100ul $529 2021-12-16 Buy

Properties

Density :1?+-.0.06 g/cm3(Predicted)
storage temp. :-20C
solubility :≥24.98 mg/mL in DMSO; ≥15.77 mg/mL in EtOH with ultrasonic; ≥18.1 mg/mL in H2O
form :White solid
pka :9.17±0.20(Predicted)
color :White to off-white

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

TNF-α converting enzyme (TACE, also known as ADAM17) is a zinc metalloprotease that cleaves the membrane-bound precursor of TNF-α to give the mature soluble form of TNF-α. It also mediates the proteolytic release of several other cell-surface proteins, including TNF-α receptors (TNFRs). TAPI-1, known in the earlier literature as just TAPI, is an inhibitor of TACE that inhibits the cleavage of TNF-α, TNFRI (p60), and TNFRII (p80) with IC50 values ranging from 5-100 μM. It also blocks the shedding of other TACE-dependent proteins, including IL-6R and Klotho, and may inhibit metalloproteases other than TACE. TAPI-1 differs from TAPI-0 , structurally, by the presence of an aminoethyl addition at the alanyl group, and is generally more stable in tissue culture and in vivo.

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