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ChemicalBook >> CAS DataBase List >> TC 14012

TC 14012

TC 14012 price.
  • $99 - $1097
  • Product name: TC 14012
  • CAS: 368874-34-4
  • MF: C90H140N34O19S2
  • MW: 2066.42
  • EINECS:
  • MDL Number:MFCD19690961
  • Synonyms:TC 14012;L-Argininamide, L-arginyl-L-arginyl-3-(2-naphthalenyl)-L-alanyl-L-cysteinyl-L-tyrosyl-N5-(aminocarbonyl)-L-ornithyl-L-lysyl-N5-(aminocarbonyl)-D-ornithyl-L-prolyl-L-tyrosyl-L-arginyl-N5-(aminocarbonyl)-L-ornithyl-L-cysteinyl-, cyclic (4→13)-disulfide;SGDDHDBBOJNZKY-LNDHEDFZSA-N;TC 14012 (TFA )
6 prices
Selected condition:
Brand
  • ApexBio Technology
  • Cayman Chemical
  • Tocris
  • Usbiological
Package
  • 5mg
  • 1
  • 1mg
  • 10mg
  • ManufacturerApexBio Technology
  • Product numberB7639
  • Product descriptionTC14012
  • Packaging10mg
  • Price$1097
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number11974
  • Product descriptionTC 14012 ≥95%
  • Packaging1mg
  • Price$99
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number11974
  • Product descriptionTC 14012 ≥95%
  • Packaging5mg
  • Price$446
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number11974
  • Product descriptionTC 14012 ≥95%
  • Packaging10mg
  • Price$792
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number4300
  • Product descriptionTC14012
  • Packaging1
  • Price$266
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number256819
  • Product descriptionTC 14012
  • Packaging1mg
  • Price$516
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ApexBio Technology B7639 TC14012 10mg $1097 2021-12-16 Buy
Cayman Chemical 11974 TC 14012 ≥95% 1mg $99 2021-12-16 Buy
Cayman Chemical 11974 TC 14012 ≥95% 5mg $446 2021-12-16 Buy
Cayman Chemical 11974 TC 14012 ≥95% 10mg $792 2021-12-16 Buy
Tocris 4300 TC14012 1 $266 2021-12-16 Buy
Usbiological 256819 TC 14012 1mg $516 2021-12-16 Buy

Properties

storage temp. :Store at -80°C
solubility :Methanol (Slightly), Water (Slightly)
form :Powder
color :White to off-white
Water Solubility :Soluble to 1 mg/ml in water
Stability :Hygroscopic

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

C-X-C chemokine receptor type 4 (CXCR4) is a receptor for the stromal cell-derived factor-1 which is designated as chemokine ligand 12 (CXCL12). It is involved in cell progression, hematopoiesis, cancer, HIV entry, and rheumatoid arthritis. TC 14012 is an antagonist of CXCR4, blocking CXCR4-mediated HIV infection with an IC50 value of 19.3 nM. In addition, TC 14012 (100 μg/ml) inhibits CXCL12-induced phosphorylation of p42/44 MAPK and STAT3 in B cells from patients with chronic lymphocytic leukemia. This peptidomimetic is C-terminally amidated, resulting in high stability in serum. TC 14012 also activates CXCR7 (EC50 = 350 nM), resulting in the recruitment of β-arrestin and Erk ? phosphorylation.