TG6-129
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- $44 - $478
- Product name: TG6-129
- CAS: 1164464-14-5
- MF: C20H18FN5O3S3
- MW: 491.58
- EINECS:
- MDL Number:
- Synonyms:TG6-129;(E)-N-(4-(N-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl)carbamothioyl)-3-(4-fluorophenyl)acrylamide;TG6-129,TG6129,inhibit,Prostaglandin Receptor,Inhibitor,TG-6-129;2-Propenamide, N-[[[4-[[(5-ethyl-1,3,4-thiadiazol-2-yl)amino]sulfonyl]phenyl]amino]thioxomethyl]-3-(4-fluorophenyl)-, (2E)-
6 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- TRC
Package
- 500μg
- 1mg
- 5mg
- 25mg
- ManufacturerAK Scientific
- Product number4658CG
- Product descriptionCID1987175
- Packaging1mg
- Price$185
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number4658CG
- Product descriptionCID1987175
- Packaging5mg
- Price$478
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19085
- Product descriptionTG6-129 ≥98%
- Packaging500μg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19085
- Product descriptionTG6-129 ≥98%
- Packaging1mg
- Price$78
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19085
- Product descriptionTG6-129 ≥98%
- Packaging5mg
- Price$341
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberT337945
- Product descriptionTG6-129
- Packaging25mg
- Price$340
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 4658CG | CID1987175 | 1mg | $185 | 2021-12-16 | Buy |
| AK Scientific | 4658CG | CID1987175 | 5mg | $478 | 2021-12-16 | Buy |
| Cayman Chemical | 19085 | TG6-129 ≥98% | 500μg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 19085 | TG6-129 ≥98% | 1mg | $78 | 2024-03-01 | Buy |
| Cayman Chemical | 19085 | TG6-129 ≥98% | 5mg | $341 | 2024-03-01 | Buy |
| TRC | T337945 | TG6-129 | 25mg | $340 | 2021-12-16 | Buy |
Properties
Density :1.518±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 8 mg/ml; DMSO: 10 mg/ml
form :A crystalline solid
pka :5.24±0.50(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 8 mg/ml; DMSO: 10 mg/ml
form :A crystalline solid
pka :5.24±0.50(Predicted)
Safety Information
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Description
Prostaglandin E2 (PGE2; ) evokes distinct responses through four different ‘E prostanoid’ (EP) receptors. EP2 is a G protein-coupled receptor that has diverse roles, including those in cancer, inflammation, and neuroprotection. TG6-129 is an antagonist of the EP2 receptor, suppressing PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 μM. It is without effect on EP4, DP1, IP, and β2-adrenergic receptors. TG6-129 reduces the expression of COX-2, IL-1β, IL-12, IL-23, IL-6, and TNF-α induced by the EP2-selective agonist butaprost in P388D1 macrophages. It has low cell cytotoxicity (CC50 = 326 μM), prolonged plasma half-life, and does not cross the blood-brain barrier.Suppliers and manufacturers
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