THIOSTREPTON
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- $6 - $1216.45
- Product name: THIOSTREPTON
- CAS: 1393-48-2
- MF: C72H85N19O18S5
- MW: 1664.89
- EINECS:215-734-9
- MDL Number:MFCD00135828
- Synonyms:Thiostrepton (200 mg);BryaMycin, Thiactin, AlaninaMide, X 146, A 8506, 6761-31;Thiostrepton, froM StreptoMyces sp.;x146 ;THIOSTREPTON;Alaninamide, L-threonyl-(4S)-2-(1Z)-1-amino-1-propenyl-4,5-dihydro-4-thiazolecarbonyl-2-(1S,2S,3R)-1-amino-2,3-dihydroxy-2-methylbutyl-4-thiazolecarbonyl-2-(5R,6S)-6-2-(1S,2R)-1-amino-2-hydroxypropyl-4-thiazolyl-5-N-(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy;THIOSTREPTION;thiostrepton from streptomyces azureus
27 prices
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Brand
- Alfa Aesar
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 1mg
- 10mg
- 5mg
- 50
- 50mg
- 250mg
- 500mg
- 1g
- 5g
- 10g
- ManufacturerAlfa Aesar
- Product numberJ62332
- Product descriptionThiostrepton, Streptomyces laurentii, 90+%
- Packaging1g
- Price$201
- Updated2024-03-01
- Buy
- ManufacturerAlfa Aesar
- Product numberJ62332
- Product descriptionThiostrepton, Streptomyces laurentii, 90+%
- Packaging5g
- Price$705
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA265605
- Product descriptionN-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+%
- Packaging1mg
- Price$6
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA265605
- Product descriptionN-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+%
- Packaging10mg
- Price$14
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA265605
- Product descriptionN-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+%
- Packaging50mg
- Price$32
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA265605
- Product descriptionN-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+%
- Packaging250mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0004400
- Product descriptionThiostrepton 95.00%
- Packaging1G
- Price$693.92
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0004400
- Product descriptionThiostrepton 95.00%
- Packaging5G
- Price$1216.45
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7336
- Product descriptionThiostrepton
- Packaging50mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIT1003
- Product descriptionThiostrepton from Streptomyces azureus
- Packaging250mg
- Price$73
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIT1003
- Product descriptionThiostrepton from Streptomyces azureus
- Packaging1g
- Price$170
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIT1003
- Product descriptionThiostrepton from Streptomyces azureus
- Packaging5g
- Price$653
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb545980
- Product descriptionThiostrepton >98%
- Packaging1g
- Price$217.6
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb545980
- Product descriptionThiostrepton >98%
- Packaging5G
- Price$620.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19200
- Product descriptionThiostrepton ≥95%
- Packaging500mg
- Price$65
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19200
- Product descriptionThiostrepton ≥95%
- Packaging1g
- Price$96
- Updated2024-03-01
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Alfa Aesar | J62332 | Thiostrepton, Streptomyces laurentii, 90+% | 1g | $201 | 2024-03-01 | Buy |
Alfa Aesar | J62332 | Thiostrepton, Streptomyces laurentii, 90+% | 5g | $705 | 2021-12-16 | Buy |
Ambeed | A265605 | N-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+% | 1mg | $6 | 2021-12-16 | Buy |
Ambeed | A265605 | N-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+% | 10mg | $14 | 2021-12-16 | Buy |
Ambeed | A265605 | N-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+% | 50mg | $32 | 2021-12-16 | Buy |
Ambeed | A265605 | N-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone 98+% | 250mg | $70 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0004400 | Thiostrepton 95.00% | 1G | $693.92 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0004400 | Thiostrepton 95.00% | 5G | $1216.45 | 2021-12-16 | Buy |
ApexBio Technology | B7336 | Thiostrepton | 50mg | $50 | 2021-12-16 | Buy |
Apolloscientific | BIT1003 | Thiostrepton from Streptomyces azureus | 250mg | $73 | 2021-12-16 | Buy |
Apolloscientific | BIT1003 | Thiostrepton from Streptomyces azureus | 1g | $170 | 2021-12-16 | Buy |
Apolloscientific | BIT1003 | Thiostrepton from Streptomyces azureus | 5g | $653 | 2021-12-16 | Buy |
Biorbyt Ltd | orb545980 | Thiostrepton >98% | 1g | $217.6 | 2021-12-16 | Buy |
Biorbyt Ltd | orb545980 | Thiostrepton >98% | 5G | $620.5 | 2021-12-16 | Buy |
Cayman Chemical | 19200 | Thiostrepton ≥95% | 500mg | $65 | 2024-03-01 | Buy |
Cayman Chemical | 19200 | Thiostrepton ≥95% | 1g | $96 | 2024-03-01 | Buy |
Properties
Melting point :248-257°C (dec.)
alpha :D23 -98.5° (glacial acetic acid); -61° (dioxane); -20° (pyridine)
Density :1.0824 (rough estimate)
refractive index :1.6700 (estimate)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO or chloroform
form :Off-white powder
pka :10.43±0.46(Predicted)
color :Off-white
Water Solubility :0.24g/L(28 ºC)
Merck :13,9440
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
alpha :D23 -98.5° (glacial acetic acid); -61° (dioxane); -20° (pyridine)
Density :1.0824 (rough estimate)
refractive index :1.6700 (estimate)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO or chloroform
form :Off-white powder
pka :10.43±0.46(Predicted)
color :Off-white
Water Solubility :0.24g/L(28 ºC)
Merck :13,9440
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
Safety Information
Symbol(GHS): |
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Signal word: | Warning | |||||||
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Precautionary statements: |
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Description
The mammalian transcription factor forkhead box M1 (FoxM1) is induced during G1 phase, with expression continuing through S phase and mitosis. Thiostrepton is a natural peptide thiazole antibiotic that inhibits FoxM1 in mammalian cells, preventing the expression of FoxM1-regulated genes, which includes FoxM1 itself. Through this mechanism, thiostrepton prevents proliferation and induces apoptosis in human cancer cells. These effects correlate with the ability of thiostrepton to act as a proteasome inhibitor.Related product price
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