TPX-0005
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- $32 - $1600
- Product name: TPX-0005
- CAS: 1802220-02-5
- MF: C18H18FN5O2
- MW: 355.37
- EINECS:125-417-3
- MDL Number:MFCD31544350
- Synonyms:TPX-0005;TPX-0005;TPX 0005;TPX0005;CS-2479;Repotrectinib(TPX-005);Repotrectinib,TPX-0005;1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)-;TPX-0005,Repotrectinib;TPX0005(Ropotrectinib)
15 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- Chemenu
- ChemScene
- DC Chemicals
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number3224EM
- Product descriptionRepotrectinib
- Packaging5mg
- Price$252
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3224EM
- Product descriptionRepotrectinib
- Packaging10mg
- Price$370
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3224EM
- Product descriptionRepotrectinib
- Packaging25mg
- Price$691
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number23397
- Product descriptionTPX-0005 ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23397
- Product descriptionTPX-0005 ≥98%
- Packaging5mg
- Price$139
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23397
- Product descriptionTPX-0005 ≥98%
- Packaging10mg
- Price$243
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23397
- Product descriptionTPX-0005 ≥98%
- Packaging25mg
- Price$533
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM327847
- Product description(3R,11S)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentazatetracyclo[13.5.2.04,9.018,22]docosa-1(21),4(9),5,7,15(22),16,19-heptaen-14-one 95%+
- Packaging250mg
- Price$78
- Updated2021-12-16
- Buy
- ManufacturerChemenu
- Product numberCM327847
- Product description(3R,11S)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentazatetracyclo[13.5.2.04,9.018,22]docosa-1(21),4(9),5,7,15(22),16,19-heptaen-14-one 95%+
- Packaging1g
- Price$194
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-7628
- Product descriptionRepotrectinib 99.81%
- Packaging5mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-7628
- Product descriptionRepotrectinib 99.81%
- Packaging10mg
- Price$210
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-7628
- Product descriptionRepotrectinib 99.81%
- Packaging25mg
- Price$420
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-7628
- Product descriptionRepotrectinib 99.81%
- Packaging50mg
- Price$590
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10463
- Product descriptionRepotrectinib(TPX-005) >98%
- Packaging100mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10463
- Product descriptionRepotrectinib(TPX-005) >98%
- Packaging1g
- Price$1600
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3224EM | Repotrectinib | 5mg | $252 | 2021-12-16 | Buy |
| AK Scientific | 3224EM | Repotrectinib | 10mg | $370 | 2021-12-16 | Buy |
| AK Scientific | 3224EM | Repotrectinib | 25mg | $691 | 2021-12-16 | Buy |
| Cayman Chemical | 23397 | TPX-0005 ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 23397 | TPX-0005 ≥98% | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 23397 | TPX-0005 ≥98% | 10mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 23397 | TPX-0005 ≥98% | 25mg | $533 | 2024-03-01 | Buy |
| Chemenu | CM327847 | (3R,11S)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentazatetracyclo[13.5.2.04,9.018,22]docosa-1(21),4(9),5,7,15(22),16,19-heptaen-14-one 95%+ | 250mg | $78 | 2021-12-16 | Buy |
| Chemenu | CM327847 | (3R,11S)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentazatetracyclo[13.5.2.04,9.018,22]docosa-1(21),4(9),5,7,15(22),16,19-heptaen-14-one 95%+ | 1g | $194 | 2021-12-16 | Buy |
| ChemScene | CS-7628 | Repotrectinib 99.81% | 5mg | $120 | 2021-12-16 | Buy |
| ChemScene | CS-7628 | Repotrectinib 99.81% | 10mg | $210 | 2021-12-16 | Buy |
| ChemScene | CS-7628 | Repotrectinib 99.81% | 25mg | $420 | 2021-12-16 | Buy |
| ChemScene | CS-7628 | Repotrectinib 99.81% | 50mg | $590 | 2021-12-16 | Buy |
| DC Chemicals | DC10463 | Repotrectinib(TPX-005) >98% | 100mg | $450 | 2021-12-16 | Buy |
| DC Chemicals | DC10463 | Repotrectinib(TPX-005) >98% | 1g | $1600 | 2021-12-16 | Buy |
Properties
Density :1.46±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:35.0(Max Conc. mg/mL);98.5(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);28.1(Max Conc. mM) form :A crystalline solid
pka :10.79±0.60(Predicted)
color :White to off-white
InChI :InChI=1S/C18H18FN5O2/c1-10-8-20-18(25)14-9-21-24-6-5-16(23-17(14)24)22-11(2)13-7-12(19)3-4-15(13)26-10/h3-7,9-11H,8H2,1-2H3,(H,20,25)(H,22,23)/t10-,11+/m0/s1
InChIKey :FIKPXCOQUIZNHB-WDEREUQCSA-N
SMILES :O1C2=CC=C(F)C=C2[C@@H](C)NC2C=CN3C(N=2)=C(C=N3)C(=O)NC[C@@H]1C
storage temp. :Store at -20°C
solubility :DMSO:35.0(Max Conc. mg/mL);98.5(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);28.1(Max Conc. mM) form :A crystalline solid
pka :10.79±0.60(Predicted)
color :White to off-white
InChI :InChI=1S/C18H18FN5O2/c1-10-8-20-18(25)14-9-21-24-6-5-16(23-17(14)24)22-11(2)13-7-12(19)3-4-15(13)26-10/h3-7,9-11H,8H2,1-2H3,(H,20,25)(H,22,23)/t10-,11+/m0/s1
InChIKey :FIKPXCOQUIZNHB-WDEREUQCSA-N
SMILES :O1C2=CC=C(F)C=C2[C@@H](C)NC2C=CN3C(N=2)=C(C=N3)C(=O)NC[C@@H]1C
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
Ropotrectinib (TPX-0005; TP Therapeutics, San Diego, CA, USA) is a nextgeneration ROS1 inhibitor, a novel three-dimensional macrocyle with a much smaller size (MW <370) than current ROS1 inhibitors. It was specifically designed to overcome resistance mutations. Preclinical studies have shown activity against gatekeeper and solvent mutations, including G2032R, D2033N, L2026M, S1986F/Y, L1951R, and kinases involved in bypass signaling such as focal adhesion kinase, SRC proto-oncogene, and non-receptor tyrosine kinase [102, 103].Related product price
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