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ChemicalBook >> CAS DataBase List >> TYRPHOSTIN AG 538

TYRPHOSTIN AG 538

TYRPHOSTIN AG 538 price.
  • $67.8 - $657.31
  • Product name: TYRPHOSTIN AG 538
  • CAS: 133550-18-2
  • MF: C16H11NO5
  • MW: 297.26
  • EINECS:
  • MDL Number:MFCD03453581
  • Synonyms:(αe)-α-[(3,4-dihydroxyphenyl)methylene]-3,4-dihydroxy-β-oxo-benzenepropanenitrile;AG 538, (αE)-α-[(3,4-Dihydroxyphenyl)methylene]-3,4-dihydroxy-β-oxo-benzenepropanenitrile;AG 538 - CAS 133550-18-2 - Calbiochem;(E)-2-(3,4-dihydroxybenzoyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile;Benzenepropanenitrile, α-[(3,4-dihydroxyphenyl)methylene]-3,4-dihydroxy-β-oxo-, (αE)-
Price2 Properties Safety Information Description
2 prices
Selected condition：
Brand
  • American Custom Chemicals Corporation
  • Sigma-Aldrich
Package
  • 5mg
  • 25MG
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000031
  • Product descriptionTYRPHOSTIN AG 538 95.00%
  • Packaging25MG
  • Price$657.31
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number658403
  • Product descriptionAG 538
  • Packaging5mg
  • Price$67.8
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation KIN0000031 TYRPHOSTIN AG 538 95.00% 25MG $657.31 2021-12-16 Buy
Sigma-Aldrich 658403 AG 538 5mg $67.8 2024-03-01 Buy

Properties

Boiling point :637.5±55.0 °C(Predicted)
Density :1.538±0.06 g/cm3(Predicted)
storage temp. :−20°C
form :solid
pka :7.48±0.35(Predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

AG 538 is a potent, competitive inhibitor of IGF-IR (IGF-1 receptor kinase, IC50 = 400 nM). Reaction is competitive with respect to IGF-1R substrate. Also inhibits the phosphorylation of PTK substrate poly(Glu,Tyr) by IGF-1R, IR, EGF-R, and Src (IC50 = 60 nM, 113 nM, 370 nM, and 2.4 μM, respectively). Inhibits the phosphorylation of PKB at a much higher concentration (IC50 = 76 μM).

Suppliers and manufacturers

TargetMol Chemicals Inc.
Tyrphostin AG 538
$100.00 /1mg
Tyrphostin AG 538 CAS:133550-18-2
Aladdin Scientific Changzhou Furuisi Biotechnology Co., Ltd Beijing Biocreative Technology Co., Ltd. Shanghai Yifei Biotechnology Co. , Ltd. TargetMol Chemicals Inc.