Tepotinib
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- $35 - $2541.5
- Product name: Tepotinib
- CAS: 1100598-32-0
- MF: C29H28N6O2
- MW: 492.57
- EINECS:
- MDL Number:MFCD18452823
- Synonyms:Benzonitrile, 3-[1,6-Dihydro-1-[[3-[5-[(1-Methyl-4-Piperidinyl)Methoxy]-2-PyriMidinyl]Phenyl]Methyl]-6-Oxo-3-Pyridazinyl];3-(1-(3-(5-((1-Methylpiperidin-4-yl)Methoxy)pyriMidin-2-yl)benzyl)-6-oxo-1,6-dihydropyridazin-3-yl)benzonitrile;3-(1-(3-(5-((1-METHYLPIPERIDIN-4-YL)METHOXY)PYRIMIDIN-2-YL)BENZYL)-1,6-DIHYDRO-6-OXOPYRIDAZIN-3-YL)B;3-[1,6-Dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]benzonitrile;Tepotinib (EMD 1214063);MSC2156119;3-[1,6-Dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]benzonitrile EMD-1214063;EMD-1214063 3-[1,6-Dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]benzonitrile
17 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- Crysdot
Package
- 1mg
- 5MG
- 10mg
- 25mg
- 10mM(in 1mL DMSO)
- 50mg
- 100mg
- 250mg
- 1000mg
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0002572
- Product descriptionEMD-1214063 95.00%
- Packaging5MG
- Price$300.3
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3388
- Product description3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile
- Packaging5mg
- Price$105
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3388
- Product description3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile
- Packaging10mM(in 1mL DMSO)
- Price$138
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3388
- Product description3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile
- Packaging10mg
- Price$155
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3388
- Product description3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile
- Packaging50mg
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3388
- Product description3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile
- Packaging100mg
- Price$700
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181238
- Product descriptionTepotinib(EMD-1214063) >98%
- Packaging100mg
- Price$690.2
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181238
- Product descriptionTepotinib(EMD-1214063) >98%
- Packaging250mg
- Price$1283.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181238
- Product descriptionTepotinib(EMD-1214063) >98%
- Packaging1000mg
- Price$2541.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18492
- Product descriptionEMD 1214063 ≥98%
- Packaging1mg
- Price$35
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18492
- Product descriptionEMD 1214063 ≥98%
- Packaging5mg
- Price$123
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18492
- Product descriptionEMD 1214063 ≥98%
- Packaging10mg
- Price$228
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18492
- Product descriptionEMD 1214063 ≥98%
- Packaging25mg
- Price$481
- Updated2021-12-16
- Buy
- ManufacturerChemenu
- Product numberCM161351
- Product description3-(1-(3-(5-((1-Methylpiperidin-4-yl)methoxy)pyrimidin-2-yl)benzyl)-6-oxo-1,6-dihydropyridazin-3-yl)benzonitrile 98%
- Packaging50mg
- Price$258
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004582
- Product descriptionEMD1214063 98+%
- Packaging10mg
- Price$231
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004582
- Product descriptionEMD1214063 98+%
- Packaging50mg
- Price$420
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | KIN0002572 | EMD-1214063 95.00% | 5MG | $300.3 | 2021-12-16 | Buy |
| ApexBio Technology | A3388 | 3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile | 5mg | $105 | 2021-12-16 | Buy |
| ApexBio Technology | A3388 | 3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile | 10mM(in 1mL DMSO) | $138 | 2021-12-16 | Buy |
| ApexBio Technology | A3388 | 3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile | 10mg | $155 | 2021-12-16 | Buy |
| ApexBio Technology | A3388 | 3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile | 50mg | $400 | 2021-12-16 | Buy |
| ApexBio Technology | A3388 | 3-[1-[[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]methyl]-6-oxopyridazin-3-yl]benzonitrile | 100mg | $700 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181238 | Tepotinib(EMD-1214063) >98% | 100mg | $690.2 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181238 | Tepotinib(EMD-1214063) >98% | 250mg | $1283.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181238 | Tepotinib(EMD-1214063) >98% | 1000mg | $2541.5 | 2021-12-16 | Buy |
| Cayman Chemical | 18492 | EMD 1214063 ≥98% | 1mg | $35 | 2021-12-16 | Buy |
| Cayman Chemical | 18492 | EMD 1214063 ≥98% | 5mg | $123 | 2021-12-16 | Buy |
| Cayman Chemical | 18492 | EMD 1214063 ≥98% | 10mg | $228 | 2021-12-16 | Buy |
| Cayman Chemical | 18492 | EMD 1214063 ≥98% | 25mg | $481 | 2021-12-16 | Buy |
| Chemenu | CM161351 | 3-(1-(3-(5-((1-Methylpiperidin-4-yl)methoxy)pyrimidin-2-yl)benzyl)-6-oxo-1,6-dihydropyridazin-3-yl)benzonitrile 98% | 50mg | $258 | 2021-12-16 | Buy |
| Crysdot | CD31004582 | EMD1214063 98+% | 10mg | $231 | 2021-12-16 | Buy |
| Crysdot | CD31004582 | EMD1214063 98+% | 50mg | $420 | 2021-12-16 | Buy |
Properties
Boiling point :626.5±65.0 °C(Predicted)
Density :1.25
storage temp. :Store at -20°C
form :Solid
pka :8.93±0.10(Predicted)
Water Solubility :≥ 4.93 mg/mL in DMSO, <2.52 mg/mL in EtOH, <2.56 mg/mL in Water
InChIKey :AHYMHWXQRWRBKT-UHFFFAOYSA-N
SMILES :C(#N)C1=CC=CC(C2=NN(CC3=CC=CC(C4=NC=C(OCC5CCN(C)CC5)C=N4)=C3)C(=O)C=C2)=C1
Density :1.25
storage temp. :Store at -20°C
form :Solid
pka :8.93±0.10(Predicted)
Water Solubility :≥ 4.93 mg/mL in DMSO, <2.52 mg/mL in EtOH, <2.56 mg/mL in Water
InChIKey :AHYMHWXQRWRBKT-UHFFFAOYSA-N
SMILES :C(#N)C1=CC=CC(C2=NN(CC3=CC=CC(C4=NC=C(OCC5CCN(C)CC5)C=N4)=C3)C(=O)C=C2)=C1
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
MET is a proto-oncogene that encodes the hepatocyte growth factor receptor c-Met. It has normal roles in morphogenesis, migration, apoptosis, and angiogenesis. Dysregulation of c-Met occurs in many types of cancer. EMD 1214063 inhibits c-Met with an IC50 value of 3 nM, demonstrating at least 1,000-fold selectivity for c-Met over a panel of 242 additional kinases. It has been shown to inhibit c-Met phosphorylation and downstream signaling in various cancer cell lines (IC50s = 6-9 nM) and, at 5-15 mg/kg, to regress tumors in mouse xenograft models.More related product prices
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![Benzonitrile, 3-[1,6-Dihydro-1-[[3-[5-[(1-Methyl-4-Piperidinyl)Methoxy]-2-PyriMidinyl]Phenyl]Methyl]-6-Oxo-3-Pyridazinyl]](https://img.chemicalbook.com/ProductImageEN/2019-12/small/c8e99c4c-c412-4599-8b63-00e0c8736d86.jpg){kind=small}