Torcetrapib
|
- $75 - $8316
- Product name: Torcetrapib
- CAS: 262352-17-0
- MF: C26H25F9N2O4
- MW: 600.47
- EINECS:
- MDL Number:MFCD09260777
- Synonyms:CP 529414;(2R)-ethyl 4-((3,5-bis(trifluoroMethyl)benzyl)(Methoxycarbonyl)aMino)-2-ethyl-6-(trifluoroMethyl)-3,4-dihydroquinoline-1(2H)-carboxylate;Torcetrapib (CP-529414);cp529;(2R,4S)-ethyl 2-ethyl-4-(methoxycarbonyl)-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate;Torcetropib;TORCETRAPIB-D3;(2R,4S)-4-[(3,5-Bis-trifluoromethylbenzyl)methoxycarbonylamino]-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester
24 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
Package
- 50mg
- 10
- 25mg
- 50
- 5mg
- 10mg
- 100mg
- 250mg
- 10mM(in 1mL DMSO)
- 1g
- 1000mg
- ManufacturerAK Scientific
- Product numberY0216
- Product descriptionTorcetrapib
- Packaging5mg
- Price$89
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberY0216
- Product descriptionTorcetrapib
- Packaging100mg
- Price$995
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4378
- Product descriptionTorcetrapib
- Packaging5mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4378
- Product descriptionTorcetrapib
- Packaging10mg
- Price$99
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4378
- Product descriptionTorcetrapib
- Packaging10mM(in 1mL DMSO)
- Price$105
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4378
- Product descriptionTorcetrapib
- Packaging50mg
- Price$378
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181337
- Product descriptionTorcetrapib >98%
- Packaging100mg
- Price$690.2
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181337
- Product descriptionTorcetrapib >98%
- Packaging250mg
- Price$1356.6
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181337
- Product descriptionTorcetrapib >98%
- Packaging1000mg
- Price$2691.1
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15028
- Product descriptionTorcetrapib ≥98%
- Packaging5mg
- Price$97
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15028
- Product descriptionTorcetrapib ≥98%
- Packaging10mg
- Price$137
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15028
- Product descriptionTorcetrapib ≥98%
- Packaging50mg
- Price$577
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-3497
- Product descriptionTorcetrapib 99.39%
- Packaging5mg
- Price$96
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3497
- Product descriptionTorcetrapib 99.39%
- Packaging10mg
- Price$119
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3497
- Product descriptionTorcetrapib 99.39%
- Packaging50mg
- Price$454
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7519
- Product descriptionTorcetrapib >98%
- Packaging100mg
- Price$450
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | Y0216 | Torcetrapib | 5mg | $89 | 2021-12-16 | Buy |
| AK Scientific | Y0216 | Torcetrapib | 100mg | $995 | 2021-12-16 | Buy |
| ApexBio Technology | A4378 | Torcetrapib | 5mg | $80 | 2021-12-16 | Buy |
| ApexBio Technology | A4378 | Torcetrapib | 10mg | $99 | 2021-12-16 | Buy |
| ApexBio Technology | A4378 | Torcetrapib | 10mM(in 1mL DMSO) | $105 | 2021-12-16 | Buy |
| ApexBio Technology | A4378 | Torcetrapib | 50mg | $378 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181337 | Torcetrapib >98% | 100mg | $690.2 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181337 | Torcetrapib >98% | 250mg | $1356.6 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181337 | Torcetrapib >98% | 1000mg | $2691.1 | 2021-12-16 | Buy |
| Cayman Chemical | 15028 | Torcetrapib ≥98% | 5mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 15028 | Torcetrapib ≥98% | 10mg | $137 | 2024-03-01 | Buy |
| Cayman Chemical | 15028 | Torcetrapib ≥98% | 50mg | $577 | 2024-03-01 | Buy |
| ChemScene | CS-3497 | Torcetrapib 99.39% | 5mg | $96 | 2021-12-16 | Buy |
| ChemScene | CS-3497 | Torcetrapib 99.39% | 10mg | $119 | 2021-12-16 | Buy |
| ChemScene | CS-3497 | Torcetrapib 99.39% | 50mg | $454 | 2021-12-16 | Buy |
| DC Chemicals | DC7519 | Torcetrapib >98% | 100mg | $450 | 2021-12-16 | Buy |
Properties
Melting point :54-58°C
Boiling point :504.8±50.0 °C(Predicted)
Density :1.42
storage temp. :Store at RT
solubility :DMSO: >5mg/mL
pka :-1.87±0.40(Predicted)
form :powder
color :white
optical activity :[α]/D >-70°
CAS DataBase Reference :262352-17-0(CAS DataBase Reference)
Boiling point :504.8±50.0 °C(Predicted)
Density :1.42
storage temp. :Store at RT
solubility :DMSO: >5mg/mL
pka :-1.87±0.40(Predicted)
form :powder
color :white
optical activity :[α]/D >-70°
CAS DataBase Reference :262352-17-0(CAS DataBase Reference)
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Cholesteryl ester transfer protein (CETP) catalyzes the exchange of cholesteryl esters from high-density lipoprotein (HDL) cholesterol to apolipoprotein B-containing lipoproteins, including very low-density lipoprotein (VLDL) and LDL. Torcetrapib is an inhibitor of CETP activity (IC50 = 50 nM) that raises HDL cholesterol and reduces LDL cholesterol levels by forming a nonproductive complex between CETP and HDL. Although torcetrapib produced consistent antiatherogenic effects in rabbits, clinical trials of torcetrapib were terminated early due to deleterious hypertensive effects. PDGFR, HGFR (c-Met), IL-2 receptor, and ErbB1- tyrosine kinase have subsequently been identified as direct off-targets of this compound.Related product price
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