Tozasertib
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- $45 - $1840
- Product name: Tozasertib
- CAS: 639089-54-6
- MF: C23H28N8OS
- MW: 464.59
- EINECS:
- MDL Number:MFCD13185152
- Synonyms:Cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino) -pyrimidin-2ylsulphanyl]-phenyl}-amide;VX-680/MK-0457;N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-(1-methylpiperidin-4-ylamino)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide;MK 0457;N-[4-[[4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide;Tozasertib;VX 680;Cyclopropanecarboxamide, N-(4-((4-(4-methyl-1-piperazinyl)-6-((5-methyl-1H-pyrazol-3-yl)amino)-2-pyrimidinyl)thio)phenyl)-
36 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
Package
- 5mg
- 10mg
- 20mg
- 25MG
- 50mg
- 250mg
- 500mg
- 10mM(in 1mL DMSO)
- 100mg
- 1g
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1092-M100
- Product descriptionTozasertib ≥95%
- Packaging100mg
- Price$378
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberW9901
- Product descriptionTozasertib
- Packaging50mg
- Price$72
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberW9901
- Product descriptionTozasertib
- Packaging100mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0001375
- Product descriptionVX-680 95.00%
- Packaging50MG
- Price$1840
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0001375
- Product descriptionVX-680 95.00%
- Packaging25MG
- Price$980
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4111
- Product descriptionVX-680(MK-0457,Tozasertib)
- Packaging50mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4111
- Product descriptionVX-680(MK-0457,Tozasertib)
- Packaging10mM(in 1mL DMSO)
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4111
- Product descriptionVX-680(MK-0457,Tozasertib)
- Packaging100mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4111
- Product descriptionVX-680(MK-0457,Tozasertib)
- Packaging250mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60184
- Product descriptionTozasertib(MK-0457)
- Packaging20mg
- Price$98
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2636
- Product descriptionTozasertib
- Packaging25mg
- Price$45
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2636
- Product descriptionTozasertib
- Packaging250mg
- Price$235
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2636
- Product descriptionTozasertib
- Packaging1g
- Price$590
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1540
- Product descriptionVX680-MK0457|Tozasertib 98%
- Packaging50mg
- Price$104.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb546008
- Product descriptionTozasertib >98%
- Packaging10mg
- Price$154.7
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb546008
- Product descriptionTozasertib >98%
- Packaging50mg
- Price$299.2
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1092-M100 | Tozasertib ≥95% | 100mg | $378 | 2021-12-16 | Buy |
| AK Scientific | W9901 | Tozasertib | 50mg | $72 | 2021-12-16 | Buy |
| AK Scientific | W9901 | Tozasertib | 100mg | $120 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001375 | VX-680 95.00% | 50MG | $1840 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001375 | VX-680 95.00% | 25MG | $980 | 2021-12-16 | Buy |
| ApexBio Technology | A4111 | VX-680(MK-0457,Tozasertib) | 50mg | $60 | 2021-12-16 | Buy |
| ApexBio Technology | A4111 | VX-680(MK-0457,Tozasertib) | 10mM(in 1mL DMSO) | $65 | 2021-12-16 | Buy |
| ApexBio Technology | A4111 | VX-680(MK-0457,Tozasertib) | 100mg | $100 | 2021-12-16 | Buy |
| ApexBio Technology | A4111 | VX-680(MK-0457,Tozasertib) | 250mg | $200 | 2021-12-16 | Buy |
| Arctom | CFN60184 | Tozasertib(MK-0457) | 20mg | $98 | 2021-12-16 | Buy |
| AvaChem | 2636 | Tozasertib | 25mg | $45 | 2021-12-16 | Buy |
| AvaChem | 2636 | Tozasertib | 250mg | $235 | 2021-12-16 | Buy |
| AvaChem | 2636 | Tozasertib | 1g | $590 | 2021-12-16 | Buy |
| Axon Medchem | Axon1540 | VX680-MK0457|Tozasertib 98% | 50mg | $104.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb546008 | Tozasertib >98% | 10mg | $154.7 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb546008 | Tozasertib >98% | 50mg | $299.2 | 2021-12-16 | Buy |
Properties
Melting point :248-253°C (dec.)
Density :1.40±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 100 mg/ml).
pka :14.09±0.70(Predicted)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Density :1.40±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 100 mg/ml).
pka :14.09±0.70(Predicted)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
The Aurora kinases (A, B, and C) are a family of serine-threonine kinases that regulate various stages of mitotic function. With significant roles in cell cycle and cell division, Aurora kinase gene amplification and overexpression are linked to tumorigenesis. MK-0457 is a potent pan-Aurora kinase inhibitor but favors Aurora A (Ki = 0.6 nM) over Aurora B (Ki = 18 nM) or Aurora C (Ki = 4.6 nM). It shows selectivity against a panel of more than 190 different protein kinases. MK-0457 effectively inhibits proliferation of several different cell lines of clear cell renal carcinoma (IC50s = <10 μM) and blocks the growth of tumors in a rodent model of cancer (80 mg/kg), inhibiting histone H3 phosphorylation and increasing apoptosis. By depleting Aurora activity, MK-0457 disrupts bipolar spindle formation during mitosis, arresting cell cycle progression at the G2/M phase.Related product price
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