U 18666A
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- $48 - $1949.9
- Product name: U 18666A
- CAS: 3039-71-2
- MF: C25H42ClNO2
- MW: 424.06
- EINECS:
- MDL Number:MFCD00210908
- Synonyms:U 18666A;3BETA-(2-DIETHYLAMINOETHOXY)ANDROST-5-EN-17 ONE, HCL;3BETA-(2-DIETHYLAMINOETHOXY)-ANDROSTENONE HCL;3BETA-(2-DIETHYLAMINO-ETHOXY)ANDROSTENONE HYDROCHLORIDE;(3BETA)-3-[2-(DIETHYLAMINO)ETHOXY]ANDROST-5-EN-17-ONE DIHYDROCHLORIDE;(3B)-3-[2-(DIETHYLAMINO)ETHOXY]ANDROST-5-EN-17-ONE HYDROCHLORIDE;U18666A,HCl;(3β)-3-[2-(diethylamino)ethoxy]androst-5-en-17-one dihydrochloride
21 prices
Selected condition：
Brand
- AK Scientific
- Alfa Aesar
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10
- 2.5mg
- 5mg
- 10mg
- 25mg
- 50mg
- 250mg
- ManufacturerAK Scientific
- Product number4494CR
- Product description3beta-(2-Diethylaminoethoxy)androst-5-en-17-onehydrochloride
- Packaging10mg
- Price$197
- Updated2021-12-16
- Buy
- ManufacturerAlfa Aesar
- Product numberJ67389
- Product descriptionU18666A 95%
- Packaging5mg
- Price$103
- Updated2023-06-20
- Buy
- ManufacturerAlfa Aesar
- Product numberJ67389
- Product descriptionU18666A 95%
- Packaging10mg
- Price$178
- Updated2023-06-20
- Buy
- ManufacturerAlfa Aesar
- Product numberJ67389
- Product descriptionU18666A 95%
- Packaging25mg
- Price$284
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6812
- Product descriptionU18666A
- Packaging10mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6812
- Product descriptionU18666A
- Packaging25mg
- Price$237
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6812
- Product descriptionU18666A
- Packaging50mg
- Price$422
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb573201
- Product descriptionU18666A
- Packaging250mg
- Price$1949.9
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number10009085
- Product descriptionU18666A ≥95%
- Packaging5mg
- Price$48
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10009085
- Product descriptionU18666A ≥95%
- Packaging10mg
- Price$89
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10009085
- Product descriptionU18666A ≥95%
- Packaging25mg
- Price$210
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number10009085
- Product descriptionU18666A ≥95%
- Packaging50mg
- Price$371
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0028465
- Product descriptionU18666A >99.0%
- Packaging5mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0028465
- Product descriptionU18666A >99.0%
- Packaging10mg
- Price$180
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC12075
- Product descriptionU18666A >98%
- Packaging250mg
- Price$1300
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberU3633
- Product descriptionU 18666A powder
- Packaging5mg
- Price$127
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 4494CR | 3beta-(2-Diethylaminoethoxy)androst-5-en-17-onehydrochloride | 10mg | $197 | 2021-12-16 | Buy |
| Alfa Aesar | J67389 | U18666A 95% | 5mg | $103 | 2023-06-20 | Buy |
| Alfa Aesar | J67389 | U18666A 95% | 10mg | $178 | 2023-06-20 | Buy |
| Alfa Aesar | J67389 | U18666A 95% | 25mg | $284 | 2021-12-16 | Buy |
| ApexBio Technology | B6812 | U18666A | 10mg | $100 | 2021-12-16 | Buy |
| ApexBio Technology | B6812 | U18666A | 25mg | $237 | 2021-12-16 | Buy |
| ApexBio Technology | B6812 | U18666A | 50mg | $422 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573201 | U18666A | 250mg | $1949.9 | 2021-12-16 | Buy |
| Cayman Chemical | 10009085 | U18666A ≥95% | 5mg | $48 | 2024-03-01 | Buy |
| Cayman Chemical | 10009085 | U18666A ≥95% | 10mg | $89 | 2024-03-01 | Buy |
| Cayman Chemical | 10009085 | U18666A ≥95% | 25mg | $210 | 2024-03-01 | Buy |
| Cayman Chemical | 10009085 | U18666A ≥95% | 50mg | $371 | 2024-03-01 | Buy |
| ChemScene | CS-0028465 | U18666A >99.0% | 5mg | $110 | 2021-12-16 | Buy |
| ChemScene | CS-0028465 | U18666A >99.0% | 10mg | $180 | 2021-12-16 | Buy |
| DC Chemicals | DC12075 | U18666A >98% | 250mg | $1300 | 2021-12-16 | Buy |
| Sigma-Aldrich | U3633 | U 18666A powder | 5mg | $127 | 2024-03-01 | Buy |
Properties
Melting point :195-196.5 °C(lit.)
storage temp. :2-8°C
solubility :H2O: 9 mg/mL at ≤60 °C
form :crystalline
color :white
Water Solubility :Soluble in water at 10mg/ml
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 week.
storage temp. :2-8°C
solubility :H2O: 9 mg/mL at ≤60 °C
form :crystalline
color :white
Water Solubility :Soluble in water at 10mg/ml
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 week.
Safety Information
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Description
Impaired trafficking of cholesterol to or from the endoplasmic reticulum (ER) has been implicated in many disease states including Neimann-Pick disease type C (NPC), Alzheimers disease and atherosclerosis. U-18666A is a cell permeable drug that inhibits cholesterol trafficking. It inhibits cholesterol transport from late endosomes/lysosomes to the endoplasmic reticulum (ER), but not cholesterol transport to the plasma membrane as demonstrated in many cell types including macrophages, primary cortical neurons and primary fibroblasts. In macrophages, micromolar concentrations of U-18666A inhibit multiple pathways of cholesterol trafficking from late endosomes, whereas nanomolar concentrations impair cholesterol trafficking to the ER, a response similar to that found in NPC. U-18666A inhibits oxidosqualene cyclase at high (>0.5 mM) concentrations and oral doses (10 mg/kg) induces cataracts in rats.Related product price
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