URMC-099
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- $29 - $1782
- Product name: URMC-099
- CAS: 1229582-33-5
- MF: C27H27N5
- MW: 421.54
- EINECS:
- MDL Number:MFCD28168077
- Synonyms:3-(1H-indol-5-yl)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridine URMC-099;URMC-099;3-(1H-indol-5-yl)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridine;1H-?Pyrrolo[2,?3-?b]?pyridine, 3-?(1H-?indol-?5-?yl)?-?5-?[4-?[(4-?methyl-?1-?piperazinyl)?methyl]?phenyl]?-;CS-1776;URMC-099;URMC 099;RMC099;inhibit,MLKs,Autophagy,URMC 099,URMC099,URMC-099,Inhibitor,Mixed Lineage Kinase
22 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- ApexBio Technology
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- DC Chemicals
- Medical Isotopes, Inc.
- TRC
Package
- 5mg
- 25mg
- 50mg
- 10mM(in 1mL DMSO)
- 1mg
- 10mg
- 100mg
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1211-M005
- Product descriptionURMC-099 ≥95%(HPLC)
- Packaging5mg
- Price$194
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1211-M100
- Product descriptionURMC-099 ≥95%(HPLC)
- Packaging100mg
- Price$1782
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX3562
- Product descriptionURMC-099
- Packaging10mg
- Price$172
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN1211
- Product descriptionURMC-099
- Packaging5mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4877
- Product descriptionURMC-099
- Packaging5mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4877
- Product descriptionURMC-099
- Packaging10mM(in 1mL DMSO)
- Price$132
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4877
- Product descriptionURMC-099
- Packaging25mg
- Price$280
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4877
- Product descriptionURMC-099
- Packaging100mg
- Price$720
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFU170951
- Product descriptionURMC 099
- Packaging50mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFU170951
- Product descriptionURMC 099
- Packaging100mg
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19147
- Product descriptionURMC-099 ≥95%
- Packaging1mg
- Price$29
- Updated2022-04-27
- Buy
- ManufacturerCayman Chemical
- Product number19147
- Product descriptionURMC-099 ≥95%
- Packaging5mg
- Price$60
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19147
- Product descriptionURMC-099 ≥95%
- Packaging10mg
- Price$99
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19147
- Product descriptionURMC-099 ≥95%
- Packaging25mg
- Price$162
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM148925
- Product description3-(1H-indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine 95%+
- Packaging10mg
- Price$211
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-4182
- Product descriptionURMC-099 99.90%
- Packaging5mg
- Price$60
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1211-M005 | URMC-099 ≥95%(HPLC) | 5mg | $194 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1211-M100 | URMC-099 ≥95%(HPLC) | 100mg | $1782 | 2021-12-16 | Buy |
| AK Scientific | X3562 | URMC-099 | 10mg | $172 | 2021-12-16 | Buy |
| AK Scientific | SYN1211 | URMC-099 | 5mg | $200 | 2021-12-16 | Buy |
| ApexBio Technology | B4877 | URMC-099 | 5mg | $95 | 2021-12-16 | Buy |
| ApexBio Technology | B4877 | URMC-099 | 10mM(in 1mL DMSO) | $132 | 2021-12-16 | Buy |
| ApexBio Technology | B4877 | URMC-099 | 25mg | $280 | 2021-12-16 | Buy |
| ApexBio Technology | B4877 | URMC-099 | 100mg | $720 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FU170951 | URMC 099 | 50mg | $250 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FU170951 | URMC 099 | 100mg | $400 | 2021-12-16 | Buy |
| Cayman Chemical | 19147 | URMC-099 ≥95% | 1mg | $29 | 2022-04-27 | Buy |
| Cayman Chemical | 19147 | URMC-099 ≥95% | 5mg | $60 | 2024-03-01 | Buy |
| Cayman Chemical | 19147 | URMC-099 ≥95% | 10mg | $99 | 2024-03-01 | Buy |
| Cayman Chemical | 19147 | URMC-099 ≥95% | 25mg | $162 | 2024-03-01 | Buy |
| Chemenu | CM148925 | 3-(1H-indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine 95%+ | 10mg | $211 | 2021-12-16 | Buy |
| ChemScene | CS-4182 | URMC-099 99.90% | 5mg | $60 | 2021-12-16 | Buy |
Properties
Density :1.256±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
form :solid
pka :13.49±0.40(Predicted)
color :Off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
form :solid
pka :13.49±0.40(Predicted)
color :Off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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Description
URMC-099 is an orally bioavailable, brain-penetrant inhibitor of mixed-lineage kinases (MLKs) with IC50 values of 19, 42, 14, and 150 nM for MLK1, MLK2, MLK3, and the related MLK family member DLK, respectively. It also inhibits LRRK2 activity with an IC50 value of 11 nM. In vitro, URMC-099 has been shown to reduce inflammatory cytokine production by HIV-1 Tat-exposed microglia and to prevent destruction and phagocytosis of cultured neuronal axons by these cells. In rodent models of HIV-associated neurocognitive disorders, URMC-099 demonstrates anti-inflammatory and neuroprotective effects.More related product prices
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