VER-49009

$82 - $1800
Product name: VER-49009
CAS: 940289-57-6
MF: C19H18ClN3O4
MW: 387.81692
EINECS:
MDL Number:MFCD18382094
Synonyms:VER-49009;CCT0129397;5-(3-chloro-4-hydroxy-6-oxocyclohexa-2,4-dien-1-ylidene)-n-ethyl-4-(4-methoxyphenyl)-1,2-dihydropyrazole-3-carboxamide;VER-49009 USP/EP/BP;3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide

Price9 Properties Safety Information Description

9 prices

Selected condition：

Brand

American Custom Chemicals Corporation
ApexBio Technology
Cayman Chemical

Package

500μg
1mg
2mg
5MG
10mg
50mg

ManufacturerAmerican Custom Chemicals Corporation
Product numberHCH0104133
Product description3-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-5-CARBOXAMIDE 95.00%
Packaging5MG
Price$496.52
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB3593
Product description3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide
Packaging2mg
Price$149
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB3593
Product description3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide
Packaging5mg
Price$293
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB3593
Product description3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide
Packaging10mg
Price$495
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB3593
Product description3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide
Packaging50mg
Price$1800
Updated2021-12-16
Buy

ManufacturerCayman Chemical
Product number13131
Product descriptionVER-49009 ≥98%
Packaging500μg
Price$82
Updated2021-12-16
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ManufacturerCayman Chemical
Product number13131
Product descriptionVER-49009 ≥98%
Packaging1mg
Price$156
Updated2021-12-16
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ManufacturerCayman Chemical
Product number13131
Product descriptionVER-49009 ≥98%
Packaging5mg
Price$656
Updated2021-12-16
Buy

ManufacturerCayman Chemical
Product number13131
Product descriptionVER-49009 ≥98%
Packaging10mg
Price$1148
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	HCH0104133	3-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-5-CARBOXAMIDE 95.00%	5MG	$496.52	2021-12-16	Buy
ApexBio Technology	B3593	3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide	2mg	$149	2021-12-16	Buy
ApexBio Technology	B3593	3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide	5mg	$293	2021-12-16	Buy
ApexBio Technology	B3593	3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide	10mg	$495	2021-12-16	Buy
ApexBio Technology	B3593	3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide	50mg	$1800	2021-12-16	Buy
Cayman Chemical	13131	VER-49009 ≥98%	500μg	$82	2021-12-16	Buy
Cayman Chemical	13131	VER-49009 ≥98%	1mg	$156	2021-12-16	Buy
Cayman Chemical	13131	VER-49009 ≥98%	5mg	$656	2021-12-16	Buy
Cayman Chemical	13131	VER-49009 ≥98%	10mg	$1148	2021-12-16	Buy

Properties

CAS DataBase Reference :940289-57-6

Safety Information

Symbol(GHS):

Signal word:

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes

Precautionary statements:

Description

The heat shock proteins (Hsps) act as molecular chaperones. Hsp90 is an abundant protein with roles in protein folding, cell signaling, and cancer. VER-49009 is a pyrazole compound that inhibits Hsp90 with an IC50 value of 47 nM. It produces a cellular antiproliferative GI50 value of 685 nM when tested against a human cancer cell line panel. Consistent with inhibition of Hsp90, VER-49009 induces the expression of Hsp27 and Hsp72 while reducing the client proteins c-Raf, B-Raf, survivin, and PRMT5, causing cell cycle arrest and apoptosis.

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