VLX1570
|
- $35 - $3800
- Product name: VLX1570
- CAS: 1431280-51-1
- MF: C23H17F2N3O6
- MW: 469.39
- EINECS:
- MDL Number:MFCD28502165
- Synonyms:VLX1570;CS-2226;VLX1570 (VLX 1570;4H-Azepin-4-one, 3,5-bis[(4-fluoro-3-nitrophenyl)methylene]hexahydro-1-(1-oxo-2-propen-1-yl)-;(3Z,5Z)-1-Acryloyl-3,5-bis(4-fluoro-3-nitrobenzylidene)azepan-4-one;1-Acryloyl-3,5-bis(4-fluoro-3-nitrobenzylidene)azepan-4-one;VLX1570,Inhibitor,Deubiquitinase,VLX-1570,DUBs,VLX 1570,inhibit;(3E,5E)-1-Acryloyl-3,5-bis(4-fluoro-3-nitrobenzylidene)hexahydro-4H-azepin-4-one
27 prices
Selected condition：
Brand
- Ambeed
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- TRC
- Usbiological
Package
- 500μg
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAmbeed
- Product numberA150004
- Product descriptionVLX1570 98+%
- Packaging1mg
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150004
- Product descriptionVLX1570 98+%
- Packaging5mg
- Price$127
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150004
- Product descriptionVLX1570 98+%
- Packaging10mg
- Price$166
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150004
- Product descriptionVLX1570 98+%
- Packaging25mg
- Price$217
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150004
- Product descriptionVLX1570 98+%
- Packaging50mg
- Price$283
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150004
- Product descriptionVLX1570 98+%
- Packaging100mg
- Price$369
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150004
- Product descriptionVLX1570 98+%
- Packaging250mg
- Price$553
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150004
- Product descriptionVLX1570 98+%
- Packaging1g
- Price$1379
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number29721
- Product descriptionVLX1570
- Packaging500μg
- Price$35
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number29721
- Product descriptionVLX1570
- Packaging1mg
- Price$36
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number29721
- Product descriptionVLX1570
- Packaging5mg
- Price$120
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number29721
- Product descriptionVLX1570 ≥98%
- Packaging10mg
- Price$223
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number29721
- Product descriptionVLX1570 ≥98%
- Packaging25mg
- Price$469
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM249400
- Product description(3Z,5Z)-1-Acryloyl-3,5-bis(4-fluoro-3-nitrobenzylidene)azepan-4-one 98%
- Packaging100mg
- Price$1374
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5402
- Product descriptionVLX1570 98.06%
- Packaging1mg
- Price$180
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5402
- Product descriptionVLX1570 98.06%
- Packaging5mg
- Price$420
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Ambeed | A150004 | VLX1570 98+% | 1mg | $75 | 2021-12-16 | Buy |
| Ambeed | A150004 | VLX1570 98+% | 5mg | $127 | 2021-12-16 | Buy |
| Ambeed | A150004 | VLX1570 98+% | 10mg | $166 | 2021-12-16 | Buy |
| Ambeed | A150004 | VLX1570 98+% | 25mg | $217 | 2021-12-16 | Buy |
| Ambeed | A150004 | VLX1570 98+% | 50mg | $283 | 2021-12-16 | Buy |
| Ambeed | A150004 | VLX1570 98+% | 100mg | $369 | 2021-12-16 | Buy |
| Ambeed | A150004 | VLX1570 98+% | 250mg | $553 | 2021-12-16 | Buy |
| Ambeed | A150004 | VLX1570 98+% | 1g | $1379 | 2021-12-16 | Buy |
| Cayman Chemical | 29721 | VLX1570 | 500μg | $35 | 2021-12-16 | Buy |
| Cayman Chemical | 29721 | VLX1570 | 1mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 29721 | VLX1570 | 5mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 29721 | VLX1570 ≥98% | 10mg | $223 | 2024-03-01 | Buy |
| Cayman Chemical | 29721 | VLX1570 ≥98% | 25mg | $469 | 2024-03-01 | Buy |
| Chemenu | CM249400 | (3Z,5Z)-1-Acryloyl-3,5-bis(4-fluoro-3-nitrobenzylidene)azepan-4-one 98% | 100mg | $1374 | 2021-12-16 | Buy |
| ChemScene | CS-5402 | VLX1570 98.06% | 1mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-5402 | VLX1570 98.06% | 5mg | $420 | 2021-12-16 | Buy |
Properties
storage temp. :Store at -20°C
solubility :DMF:25.0(Max Conc. mg/mL);53.26(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.64(Max Conc. mM)
DMSO:47.0(Max Conc. mg/mL);100.13(Max Conc. mM) form :A crystalline solid
color :Light yellow to yellow
solubility :DMF:25.0(Max Conc. mg/mL);53.26(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.64(Max Conc. mM)
DMSO:47.0(Max Conc. mg/mL);100.13(Max Conc. mM) form :A crystalline solid
color :Light yellow to yellow
Safety Information
| Symbol(GHS): |
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
VLX1570 is an inhibitor of 19S proteasomal deubiquitinases with IC50 values of 6.4 and 13 μM for deubiquitinase activity in vitro using Ub-rhodamine and Ub-AMC, respectively, as substrates. It is selective for proteasomal deubiquitinases over a panel of deubiquitinases at 20 μM, but inhibits USP5 by greater than 50%, and over a panel of 211 kinases at 10 μM, but inhibits Cdk4 by 77%. VLX1570 binds to and inhibits recombinant ubiquitin-specific protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5) in vitro, and inhibits the USP14 and UCHL5 activity of purified 19S proteasomes when used at a concentration of 50 μM. It inhibits the proliferation of KMS-11, RPMI-8226, OPM-2, and OPM-2-BZR multiple myeloma cells (IC50s = 43, 74, 126, and 191 nM, respectively), as well as induces apoptosis and increases the accumulation of polyubiquitinated proteins. VLX1570 (3 mg/kg per day for 10 days) increases survival and reduces tumor growth in KMS-11-LUC2 and RPMI-8226 mouse xenograft models, respectively.More related product prices
VLX600Related product price
- VLX600
$37-1800
