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ChemicalBook >> CAS DataBase List >> VS-5584

VS-5584

VS-5584 price.
  • $32 - $2395.3
  • Product name: VS-5584
  • CAS: 1246560-33-7
  • MF: C17H22N8O
  • MW: 354.41
  • EINECS:
  • MDL Number:MFCD25372027
  • Synonyms:2-Pyrimidinamine, 5-[8-methyl-9-(1-methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]-;5-[8-Methyl-9-(1-methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]-2-pyrimidinamine VS-5584;VS-5584, >=98%;VS-5584;SB 2343;SB2343;5-(9-Isopropyl-8-Methyl-2-Morpholin-4-yl-9H-purin-6-yl)-pyriMidin-2-ylaMine;5-(9-ISOPROPYL-8-METHYL-2-MORPHOLINO-9H-PURIN-6-YL)PYRIMIDIN-2-AMINE
20 prices
Selected condition:
Brand
  • AK Scientific
  • ApexBio Technology
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
Package
  • 1mg
  • 5mg
  • 10mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 1000mg
  • ManufacturerAK Scientific
  • Product number2797AH
  • Product description5-(9-Isopropyl-8-methyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine
  • Packaging1mg
  • Price$133
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2797AH
  • Product description5-(9-Isopropyl-8-methyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine
  • Packaging10mg
  • Price$353
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3927
  • Product descriptionVS-5584(SB2343)
  • Packaging50mg
  • Price$400
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180870
  • Product descriptionVS-5584 >98%
  • Packaging100mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180870
  • Product descriptionVS-5584 >98%
  • Packaging250mg
  • Price$1208.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180870
  • Product descriptionVS-5584 >98%
  • Packaging1000mg
  • Price$2395.3
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16294
  • Product descriptionVS-5584 ≥98%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16294
  • Product descriptionVS-5584 ≥98%
  • Packaging5mg
  • Price$139
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16294
  • Product descriptionVS-5584 ≥98%
  • Packaging10mg
  • Price$230
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM138601
  • Product description5-(9-Isopropyl-8-methyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine 98%
  • Packaging50mg
  • Price$324
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1202
  • Product descriptionVS-5584 98.15%
  • Packaging5mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1202
  • Product descriptionVS-5584 98.15%
  • Packaging10mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1202
  • Product descriptionVS-5584 98.15%
  • Packaging50mg
  • Price$400
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1202
  • Product descriptionVS-5584 98.15%
  • Packaging100mg
  • Price$650
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004110
  • Product descriptionVS-5584 98+%
  • Packaging5mg
  • Price$76
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004110
  • Product descriptionVS-5584 98+%
  • Packaging10mg
  • Price$102
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2797AH 5-(9-Isopropyl-8-methyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine 1mg $133 2021-12-16 Buy
AK Scientific 2797AH 5-(9-Isopropyl-8-methyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine 10mg $353 2021-12-16 Buy
ApexBio Technology A3927 VS-5584(SB2343) 50mg $400 2021-12-16 Buy
Biorbyt Ltd orb180870 VS-5584 >98% 100mg $615.4 2021-12-16 Buy
Biorbyt Ltd orb180870 VS-5584 >98% 250mg $1208.7 2021-12-16 Buy
Biorbyt Ltd orb180870 VS-5584 >98% 1000mg $2395.3 2021-12-16 Buy
Cayman Chemical 16294 VS-5584 ≥98% 1mg $32 2024-03-01 Buy
Cayman Chemical 16294 VS-5584 ≥98% 5mg $139 2024-03-01 Buy
Cayman Chemical 16294 VS-5584 ≥98% 10mg $230 2024-03-01 Buy
Chemenu CM138601 5-(9-Isopropyl-8-methyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine 98% 50mg $324 2021-12-16 Buy
ChemScene CS-1202 VS-5584 98.15% 5mg $90 2021-12-16 Buy
ChemScene CS-1202 VS-5584 98.15% 10mg $120 2021-12-16 Buy
ChemScene CS-1202 VS-5584 98.15% 50mg $400 2021-12-16 Buy
ChemScene CS-1202 VS-5584 98.15% 100mg $650 2021-12-16 Buy
Crysdot CD31004110 VS-5584 98+% 5mg $76 2021-12-16 Buy
Crysdot CD31004110 VS-5584 98+% 10mg $102 2021-12-16 Buy

Properties

Boiling point :687.2±65.0 °C(Predicted)
Density :1.48±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥17.7 mg/mL in DMSO; ≥4.71 mg/mL in EtOH with ultrasonic
form :solid
pka :4.53±0.10(Predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P273 Avoid release to the environment.
P501 Dispose of contents/container to..…

Description

Phosphatidylinositol 3-kinase (PI3K) signaling through Akt/PKB and the mammalian target of rapamycin (mTOR) controls gene expression related to cell proliferation, differentiation, and apoptosis. Increased activity of this pathway is important in many types of cancer. VS-5584 is a purine analog that inhibits mTOR (IC50 = 37 nM) and PI3K (IC50s = 16, 68, 25, and 42 nM for the α, β, γ, and δ isoforms, respectively) without relevant activity against more than 400 additional lipid and protein kinases. By inhibiting the phosphorylation of substrates downstream of PI3K and mTOR, VS-5584 demonstrates broad anti-proliferative sensitivity leading to tumor growth inhibition in human tumor models.

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