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ChemicalBook >> (+)-YK-4-279

(+)-YK-4-279

(+)-YK-4-279 price.
  • $60 - $1050
  • Product name: (+)-YK-4-279
  • CAS: 1261038-93-0
  • MF: C17H13Cl2NO4
  • MW: 366.2
  • EINECS:
  • MDL Number:
  • Synonyms:(3R)-4,7-dichloro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-1H-indol-2-one;2H-Indol-2-one, 4,7-dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-, (3R)-
Price4 Properties Safety Information Description
4 prices
Selected condition：
Brand
  • Cayman Chemical
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • ManufacturerCayman Chemical
  • Product number11167
  • Product description(+)-YK-4-279 ≥98%
  • Packaging1mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number11167
  • Product description(+)-YK-4-279 ≥98%
  • Packaging5mg
  • Price$270
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number11167
  • Product description(+)-YK-4-279 ≥98%
  • Packaging10mg
  • Price$480
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number11167
  • Product description(+)-YK-4-279 ≥98%
  • Packaging25mg
  • Price$1050
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Cayman Chemical 11167 (+)-YK-4-279 ≥98% 1mg $60 2021-12-16 Buy
Cayman Chemical 11167 (+)-YK-4-279 ≥98% 5mg $270 2021-12-16 Buy
Cayman Chemical 11167 (+)-YK-4-279 ≥98% 10mg $480 2021-12-16 Buy
Cayman Chemical 11167 (+)-YK-4-279 ≥98% 25mg $1050 2021-12-16 Buy

Properties

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Ewing’s sarcoma is characterized by the formation of an oncogenic fusion protein, EWS-FLI1, which binds to RNA helicase central to disease. YK-4-279 binds to EWS-FLI1 (Kd = 9.48 μM), blocking the interaction of EWS-FLI1 and RNA helicase and driving apoptosis in Ewing’s sarcoma family tumors. Through these effects, YK-4-279 reduces the growth of Ewing’s sarcoma orthotopic xenografts. Importantly, it is effective in Ewing’s sarcoma cells, both in vitro and in vivo, that are chemotherapy-resistant. YK-4-279 also binds the ETS transcription factors ERG and ETV1 (Kd = 11.7 and 17.4, respectively), which form fusion proteins that contribute to some types of prostate cancer. (+)-YK-4-279 is a highly purified enantiomer of YK-4-279. Its properties have not been characterized.

Suppliers and manufacturers

Cayman Chemical Company