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ChemicalBook >> CAS DataBase List >> Z-FL-COCHO

Z-FL-COCHO

Z-FL-COCHO price.
  • $42 - $1238
  • Product name: Z-FL-COCHO
  • CAS: 1373215-15-6
  • MF: C25H29FN4O5
  • MW: 484.52
  • EINECS:
  • MDL Number:MFCD04974155
  • Synonyms:Z-FL-COCHO;((3R,4S)-4-((4-FLUOROBENZOYL)AMINO)-6-(4-(OXETAN-3-YL)PIPERAZIN-1-YL)CHROMAN-3-YL)N-METHYLCARBAMATE;CATHEPSIN S INHIBITOR;N-[(3R,4S)-3,4-Dihydro-3-[[(methylamino)carbonyl]oxy]-6-[4-(3-oxetanyl)-1-piperazinyl]-2H-1-benzopyran-4-yl]-4-fluorobenzamide;LY 3000328;Benzamide, N-[(3R,4S)-3,4-dihydro-3-[[(methylamino)carbonyl]oxy]-6-[4-(3-oxetanyl)-1-piperazinyl]-2H-1-benzopyran-4-yl]-4-fluoro-;(3R,4S)-4-(4-fluorobenzamido)-6-(4-(oxetan-3-yl)piperazin-1-yl)chroman-3-yl methylcarbamate;CATHEPSIN S INHIBITOR ;LY-3000328;LY3000328
23 prices
Selected condition:
Brand
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • TRC
Package
  • 10mM(in 1mL DMSO)
  • 500μg
  • 1mg
  • 2.5mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • ManufacturerAK Scientific
  • Product number3527AH
  • Product descriptionCathepsinSinhibitor
  • Packaging10mg
  • Price$444
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA473978
  • Product descriptionLY3000328 98+%
  • Packaging1mg
  • Price$42
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA473978
  • Product descriptionLY3000328 98+%
  • Packaging5mg
  • Price$92
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA473978
  • Product descriptionLY3000328 98+%
  • Packaging10mg
  • Price$135
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA473978
  • Product descriptionLY3000328 98+%
  • Packaging25mg
  • Price$204
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA473978
  • Product descriptionLY3000328 98+%
  • Packaging50mg
  • Price$304
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA473978
  • Product descriptionLY3000328 98+%
  • Packaging100mg
  • Price$455
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3284
  • Product descriptionCathepsinSinhibitor
  • Packaging5mg
  • Price$212
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3284
  • Product descriptionCathepsinSinhibitor
  • Packaging10mM(in 1mL DMSO)
  • Price$250
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3284
  • Product descriptionCathepsinSinhibitor
  • Packaging10mg
  • Price$275
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number29729
  • Product descriptionLY3000328
  • Packaging500μg
  • Price$81
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29729
  • Product descriptionLY3000328
  • Packaging1mg
  • Price$152
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29729
  • Product descriptionLY3000328
  • Packaging5mg
  • Price$356
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29729
  • Product descriptionLY3000328
  • Packaging10mg
  • Price$632
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM162803
  • Product description(3R,4S)-4-(4-fluorobenzamido)-6-(4-(oxetan-3-yl)piperazin-1-yl)chroman-3-ylmethylcarbamate 98%
  • Packaging50mg
  • Price$628
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1120
  • Product descriptionLY3000328 99.35%
  • Packaging10mg
  • Price$354
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3527AH CathepsinSinhibitor 10mg $444 2021-12-16 Buy
Ambeed A473978 LY3000328 98+% 1mg $42 2021-12-16 Buy
Ambeed A473978 LY3000328 98+% 5mg $92 2021-12-16 Buy
Ambeed A473978 LY3000328 98+% 10mg $135 2021-12-16 Buy
Ambeed A473978 LY3000328 98+% 25mg $204 2021-12-16 Buy
Ambeed A473978 LY3000328 98+% 50mg $304 2021-12-16 Buy
Ambeed A473978 LY3000328 98+% 100mg $455 2021-12-16 Buy
ApexBio Technology A3284 CathepsinSinhibitor 5mg $212 2021-12-16 Buy
ApexBio Technology A3284 CathepsinSinhibitor 10mM(in 1mL DMSO) $250 2021-12-16 Buy
ApexBio Technology A3284 CathepsinSinhibitor 10mg $275 2021-12-16 Buy
Cayman Chemical 29729 LY3000328 500μg $81 2024-03-01 Buy
Cayman Chemical 29729 LY3000328 1mg $152 2024-03-01 Buy
Cayman Chemical 29729 LY3000328 5mg $356 2024-03-01 Buy
Cayman Chemical 29729 LY3000328 10mg $632 2024-03-01 Buy
Chemenu CM162803 (3R,4S)-4-(4-fluorobenzamido)-6-(4-(oxetan-3-yl)piperazin-1-yl)chroman-3-ylmethylcarbamate 98% 50mg $628 2021-12-16 Buy
ChemScene CS-1120 LY3000328 99.35% 10mg $354 2021-12-16 Buy

Properties

Boiling point :701.6±60.0 °C(Predicted)
Density :1.38±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥24.25 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :Powder
pka :12.50±0.46(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

LY3000328 is a potent cathepsin S inhibitor (IC50 = 7.7 nM for the human enzyme). It is selective for cathepsin S over cathepsin L, K, B, and V (IC50s = >10,000, >10,000, 4,390, and 21,500 nM, respectively). LY3000328 (1-30 mg/kg) reduces aortic diameter in a mouse model of calcium chloride-induced abdominal aortic aneurysm.