Crisaborole
|
- $45 - $3590
- Product name: Crisaborole
- CAS: 906673-24-3
- MF: C14H10BNO3
- MW: 251.05
- EINECS:250-635-4
- MDL Number:MFCD17169940
- Synonyms:AN-2728, >=98%;AN2728, Crisaborole;Crisaborole (AN2728);AN 2728;AN2728/AN-2728;4-((1-Hydroxy-1,3-dihydrobenzo-[c][1,2]oxaborol-5-yl)oxy)benzonitrile;4-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]benzonitrile;AN-2728;AN2728;AN 2728
32 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- TRC
Package
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- 250MG
- 500mg
- 1g
- 25g
- 10mM(in 1mL DMSO)
- ManufacturerAK Scientific
- Product number5098AC
- Product description4-((1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)benzonitrile
- Packaging10mg
- Price$115
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0013781
- Product descriptionAN-2728 95.00%
- Packaging5MG
- Price$479
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0013781
- Product descriptionAN-2728 95.00%
- Packaging250MG
- Price$3590
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3178
- Product descriptionAN-2728
- Packaging10mg
- Price$45
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3178
- Product descriptionAN-2728
- Packaging10mM(in 1mL DMSO)
- Price$61
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3178
- Product descriptionAN-2728
- Packaging50mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon3169
- Product descriptionCrisaborole-AN2728 99%
- Packaging10mg
- Price$66
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC166718
- Product descriptionCrisaborole
- Packaging25mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC166718
- Product descriptionCrisaborole
- Packaging50mg
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC166718
- Product descriptionCrisaborole
- Packaging100mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC166718
- Product descriptionCrisaborole
- Packaging250mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC166718
- Product descriptionCrisaborole
- Packaging500mg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number21455
- Product descriptionAN2728 ≥98%
- Packaging25mg
- Price$62
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21455
- Product descriptionAN2728 ≥98%
- Packaging50mg
- Price$115
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21455
- Product descriptionAN2728 ≥98%
- Packaging100mg
- Price$216
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21455
- Product descriptionAN2728 ≥98%
- Packaging250mg
- Price$448
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 5098AC | 4-((1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)benzonitrile | 10mg | $115 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0013781 | AN-2728 95.00% | 5MG | $479 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0013781 | AN-2728 95.00% | 250MG | $3590 | 2021-12-16 | Buy |
| ApexBio Technology | A3178 | AN-2728 | 10mg | $45 | 2021-12-16 | Buy |
| ApexBio Technology | A3178 | AN-2728 | 10mM(in 1mL DMSO) | $61 | 2021-12-16 | Buy |
| ApexBio Technology | A3178 | AN-2728 | 50mg | $70 | 2021-12-16 | Buy |
| Axon Medchem | Axon3169 | Crisaborole-AN2728 99% | 10mg | $66 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC166718 | Crisaborole | 25mg | $50 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC166718 | Crisaborole | 50mg | $75 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC166718 | Crisaborole | 100mg | $120 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC166718 | Crisaborole | 250mg | $200 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC166718 | Crisaborole | 500mg | $350 | 2021-12-16 | Buy |
| Cayman Chemical | 21455 | AN2728 ≥98% | 25mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 21455 | AN2728 ≥98% | 50mg | $115 | 2024-03-01 | Buy |
| Cayman Chemical | 21455 | AN2728 ≥98% | 100mg | $216 | 2024-03-01 | Buy |
| Cayman Chemical | 21455 | AN2728 ≥98% | 250mg | $448 | 2024-03-01 | Buy |
Properties
Melting point :>130°C (softened)
Boiling point :425.9±55.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO (Slightly), Methanol (Slightly)
pka :7.00±0.20(Predicted)
form :powder
color :white to beige
Stability :Hygroscopic
InChI :InChI=1S/C14H10BNO3/c16-8-10-1-3-12(4-2-10)19-13-5-6-14-11(7-13)9-18-15(14)17/h1-7,17H,9H2
InChIKey :USZAGAREISWJDP-UHFFFAOYSA-N
SMILES :C(#N)C1=CC=C(OC2=CC=C3B(O)OCC3=C2)C=C1
Boiling point :425.9±55.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO (Slightly), Methanol (Slightly)
pka :7.00±0.20(Predicted)
form :powder
color :white to beige
Stability :Hygroscopic
InChI :InChI=1S/C14H10BNO3/c16-8-10-1-3-12(4-2-10)19-13-5-6-14-11(7-13)9-18-15(14)17/h1-7,17H,9H2
InChIKey :USZAGAREISWJDP-UHFFFAOYSA-N
SMILES :C(#N)C1=CC=C(OC2=CC=C3B(O)OCC3=C2)C=C1
Safety Information
| Symbol(GHS): |
|
||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Danger | ||||||||||||||||||||||||||||
| Hazard statements: |
|
||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
Crisaborole is a phosphodiesterase- 4 (PDE4) inhibitor that was approved by FDA on December 14, 2016 as Eucrisa, a topical treatment of for mild to moderate atopic dermatitis (AD) in patients aged two years and older. The drug, which was developed by Anacor Pharmaceuticals and later acquired and marketed by Pfizer, is delivered as a 2% ointment, which is applied topically. Its structure contains a boron atom, which facilitates skin penetration and binding to the bimetal center of the phosphodiesterase 4 enzyme. The unique employment of boron within the chemical structure of the drug is designed to enable selective engagement of PDE4 (an enzyme involved in the conversion of cAMP into AMP, which signals for downstream inflammatory events), effective penetration of the drug through human skin, and rapid clearance to limit systemic circulation.Suppliers and manufacturers
HAINAN POLY PHARMCEUTICAL CO. LTD
Shenzhen Excellent Biomedical Technology Co.,Ltd.
Shandong Shengzhiyuan Biotechnology Co., LTD
![4-((1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)benzonitrile](/ProductImageEN/2023-10/small/bddf0fb7-e5bb-433a-8580-965997da3abd.jpg){kind=small}
