GLIOTOXIN
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- $57 - $801
- Product name: GLIOTOXIN
- CAS: 67-99-2
- MF: C13H14N2O4S2
- MW: 326.39
- EINECS:636-170-3
- MDL Number:MFCD00058534
- Synonyms:GLIOTOXIN;GLIOTOXIN, GLADIOCLADIUM FIMBRIATUM;2,3,5A,6-TETRAHYDRO-6-HYDROXY-3(HYROXYMETHYL)-2-METHYL-10H-3A, 10A-EPIDITHIO-PYRAZINOL[1,2ALPHA]INDOLE-1,4-DIONE;(3r-(3-alpha,5a-beta,6-beta,10a-alpha))-ymethyl)-2-methyl ;10h-3,10a-epidithiopyrazino(1,2-a)indole-1,4-dione,2,3,5a,6-hydroxy-3-(hydrox ;aspergillin ;s.n.12870 ;gliotoxin from gliocladium fimbriatum
21 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- AvaChem
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 1
- 1mg
- 5mg
- 10mg
- 20mg
- 25mg
- ManufacturerAK Scientific
- Product number8679AJ
- Product descriptionGliotoxin
- Packaging5mg
- Price$337
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4443
- Product descriptionGliotoxin
- Packaging5mg
- Price$244
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4443
- Product descriptionGliotoxin
- Packaging10mg
- Price$432
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3233
- Product descriptionGliotoxin
- Packaging1mg
- Price$89
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3233
- Product descriptionGliotoxin
- Packaging5mg
- Price$390
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3233
- Product descriptionGliotoxin
- Packaging20mg
- Price$790
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb545964
- Product descriptionGliotoxin >98%
- Packaging1mg
- Price$217.6
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb545964
- Product descriptionGliotoxin >98%
- Packaging5mg
- Price$620.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number11433
- Product descriptionGliotoxin ≥98%
- Packaging1mg
- Price$57
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number11433
- Product descriptionGliotoxin ≥98%
- Packaging5mg
- Price$253
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number11433
- Product descriptionGliotoxin ≥98%
- Packaging10mg
- Price$422
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0029133
- Product descriptionGliotoxin >98.0%
- Packaging5mg
- Price$420
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number65104
- Product descriptionGliotoxin
- Packaging1mg
- Price$290
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product number371715
- Product descriptionGliotoxin from Gliocladium fimbriatum
- Packaging1mg
- Price$167
- Updated2023-01-07
- Buy
- ManufacturerSigma-Aldrich
- Product numberG9893
- Product descriptionGliotoxin from Gliocladium fimbriatum
- Packaging5mg
- Price$255
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberG9893
- Product descriptionGliotoxin from Gliocladium fimbriatum
- Packaging25mg
- Price$801
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 8679AJ | Gliotoxin | 5mg | $337 | 2021-12-16 | Buy |
| ApexBio Technology | A4443 | Gliotoxin | 5mg | $244 | 2021-12-16 | Buy |
| ApexBio Technology | A4443 | Gliotoxin | 10mg | $432 | 2021-12-16 | Buy |
| AvaChem | 3233 | Gliotoxin | 1mg | $89 | 2021-12-16 | Buy |
| AvaChem | 3233 | Gliotoxin | 5mg | $390 | 2021-12-16 | Buy |
| AvaChem | 3233 | Gliotoxin | 20mg | $790 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb545964 | Gliotoxin >98% | 1mg | $217.6 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb545964 | Gliotoxin >98% | 5mg | $620.5 | 2021-12-16 | Buy |
| Cayman Chemical | 11433 | Gliotoxin ≥98% | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 11433 | Gliotoxin ≥98% | 5mg | $253 | 2024-03-01 | Buy |
| Cayman Chemical | 11433 | Gliotoxin ≥98% | 10mg | $422 | 2024-03-01 | Buy |
| ChemScene | CS-0029133 | Gliotoxin >98.0% | 5mg | $420 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 65104 | Gliotoxin | 1mg | $290 | 2021-12-16 | Buy |
| Sigma-Aldrich | 371715 | Gliotoxin from Gliocladium fimbriatum | 1mg | $167 | 2023-01-07 | Buy |
| Sigma-Aldrich | G9893 | Gliotoxin from Gliocladium fimbriatum | 5mg | $255 | 2024-03-01 | Buy |
| Sigma-Aldrich | G9893 | Gliotoxin from Gliocladium fimbriatum | 25mg | $801 | 2024-03-01 | Buy |
Properties
Melting point :221°C (rough estimate)
Boiling point :699.7±55.0 °C(Predicted)
alpha :D25 -290° (c = 0.08 in ethanol)
Density :1.4069 (rough estimate)
refractive index :1.6510 (estimate)
Flash point :2℃
storage temp. :2-8°C
solubility :chloroform: 10 mg/mL, clear, colorless
form :White solid
pka :12.90±0.40(Predicted)
color :Monoclinic crystals from MeOH
Merck :13,4454
BRN :50675
Stability :Stable for 2 yeara as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Boiling point :699.7±55.0 °C(Predicted)
alpha :D25 -290° (c = 0.08 in ethanol)
Density :1.4069 (rough estimate)
refractive index :1.6510 (estimate)
Flash point :2℃
storage temp. :2-8°C
solubility :chloroform: 10 mg/mL, clear, colorless
form :White solid
pka :12.90±0.40(Predicted)
color :Monoclinic crystals from MeOH
Merck :13,4454
BRN :50675
Stability :Stable for 2 yeara as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains of Aspergillus and other fungi. It inhibits 20S proteasomal chymotrypsin activity (IC50 = 10 μM), blocking the degradation of IκBα and preventing the activation of NF-κB. Gliotoxin also induces apoptosis in monocytes and dendritic cells and reduces phagocytosis by neutrophils. It also inhibits geranylgeranyltransferase I and farnesyltransferase (IC50 = 17 and 80 μM, respectively). Gliotoxin potently suppresses viral infection by Nipah and Hendra virus in vitro (IC50 = 149 and 579 nM, respectively). While gliotoxin production by fungi correlates with invasiveness, its role in aspergillosis remains unclear.More related product prices
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