macitentan
|
- $39 - $2397
- Product name: macitentan
- CAS: 441798-33-0
- MF: C19H20Br2N6O4S
- MW: 588.27
- EINECS:1308068-626-2
- MDL Number:MFCD17167076
- Synonyms:N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)-oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfami;macitentan;N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide;ACT 064992;ACT-064992;ACT-064992 / ACT064992;Macitentan, >=99%;SulfaMide,N-[5-(4-broMophenyl)-6-[2-[(5-broMo-2-pyriMidinyl)oxy]ethoxy]-4-pyriMidinyl]-N'-propyl-
20 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Labseeker
- Matrix Scientific
- Medical Isotopes, Inc.
Package
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 5g
- 10g
- ManufacturerAK Scientific
- Product numberX6162
- Product descriptionMacitentan
- Packaging100mg
- Price$2397
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1929
- Product descriptionMacitentan
- Packaging5mg
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146064
- Product descriptionMacitentan (Actelion-1,ACT-064992) >99%
- Packaging100mg
- Price$510
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146064
- Product descriptionMacitentan (Actelion-1,ACT-064992) >99%
- Packaging250mg
- Price$615.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146064
- Product descriptionMacitentan (Actelion-1,ACT-064992) >99%
- Packaging1g
- Price$1208.7
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBM162771
- Product descriptionMacitentan
- Packaging10mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBM162771
- Product descriptionMacitentan
- Packaging50mg
- Price$214
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number23304
- Product descriptionMacitentan ≥98%
- Packaging25mg
- Price$39
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23304
- Product descriptionMacitentan ≥98%
- Packaging50mg
- Price$73
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23304
- Product descriptionMacitentan ≥98%
- Packaging100mg
- Price$138
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number23304
- Product descriptionMacitentan ≥98%
- Packaging250mg
- Price$302
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0686
- Product descriptionMacitentan 99.87%
- Packaging5mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0686
- Product descriptionMacitentan 99.87%
- Packaging10mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0686
- Product descriptionMacitentan 99.87%
- Packaging50mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0686
- Product descriptionMacitentan 99.87%
- Packaging100mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC1012
- Product descriptionMacitentan(Actelion-1,ACT-064992) 99.00%
- Packaging100mg
- Price$250
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X6162 | Macitentan | 100mg | $2397 | 2021-12-16 | Buy |
| ApexBio Technology | A1929 | Macitentan | 5mg | $55 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146064 | Macitentan (Actelion-1,ACT-064992) >99% | 100mg | $510 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146064 | Macitentan (Actelion-1,ACT-064992) >99% | 250mg | $615.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146064 | Macitentan (Actelion-1,ACT-064992) >99% | 1g | $1208.7 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BM162771 | Macitentan | 10mg | $90 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BM162771 | Macitentan | 50mg | $214 | 2021-12-16 | Buy |
| Cayman Chemical | 23304 | Macitentan ≥98% | 25mg | $39 | 2024-03-01 | Buy |
| Cayman Chemical | 23304 | Macitentan ≥98% | 50mg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 23304 | Macitentan ≥98% | 100mg | $138 | 2024-03-01 | Buy |
| Cayman Chemical | 23304 | Macitentan ≥98% | 250mg | $302 | 2024-03-01 | Buy |
| ChemScene | CS-0686 | Macitentan 99.87% | 5mg | $50 | 2021-12-16 | Buy |
| ChemScene | CS-0686 | Macitentan 99.87% | 10mg | $70 | 2021-12-16 | Buy |
| ChemScene | CS-0686 | Macitentan 99.87% | 50mg | $100 | 2021-12-16 | Buy |
| ChemScene | CS-0686 | Macitentan 99.87% | 100mg | $150 | 2021-12-16 | Buy |
| DC Chemicals | DC1012 | Macitentan(Actelion-1,ACT-064992) 99.00% | 100mg | $250 | 2021-12-16 | Buy |
Properties
Boiling point :692.4±65.0 °C(Predicted)
Density :1.675
storage temp. :Store at -20°C
solubility :≥24.4 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :4.99±0.50(Predicted)
color :White to off-white
InChI :InChI=1S/C19H20Br2N6O4S/c1-2-7-26-32(28,29)27-17-16(13-3-5-14(20)6-4-13)18(25-12-24-17)30-8-9-31-19-22-10-15(21)11-23-19/h3-6,10-12,26H,2,7-9H2,1H3,(H,24,25,27)
InChIKey :JGCMEBMXRHSZKX-UHFFFAOYSA-N
SMILES :S(NC1C(C2=CC=C(Br)C=C2)=C(OCCOC2=NC=C(Br)C=N2)N=CN=1)(NCCC)(=O)=O
Density :1.675
storage temp. :Store at -20°C
solubility :≥24.4 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :4.99±0.50(Predicted)
color :White to off-white
InChI :InChI=1S/C19H20Br2N6O4S/c1-2-7-26-32(28,29)27-17-16(13-3-5-14(20)6-4-13)18(25-12-24-17)30-8-9-31-19-22-10-15(21)11-23-19/h3-6,10-12,26H,2,7-9H2,1H3,(H,24,25,27)
InChIKey :JGCMEBMXRHSZKX-UHFFFAOYSA-N
SMILES :S(NC1C(C2=CC=C(Br)C=C2)=C(OCCOC2=NC=C(Br)C=N2)N=CN=1)(NCCC)(=O)=O
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
Macitentan (also known as ACT-064992) received US FDA approval in October 2013 for the treatment of pulmonary arterial hypertension (PAH) (WHO group I) to delay disease progression. Treatment options include phosphodiesterase type 5 inhibitors, prostacyclins, and the endothelin receptor antagonists bosentan and ambrisentan. Macitentan was discovered through SAR studies starting with the bosentan structure with three main goals: (1) to increase potency for both endothelin receptor A and B (ETA and ETB) subtypes; (2) to improve tissue distribution to reach the target receptors; and (3) to avoid bile salt transport inhibition. Starting with the bosentan sulfonamido-pyrimidinyl central core, potency was increased 10-fold via incorporation of a bromopyrimidinyl ethylene glycol ether, as found in the clinical endothelin antagonist, T-0201. An aryl ether in bosentan was replaced with the bromophenyl group in macitentan, and a substituent on the 2-position of the central pyrimidine was replaced with hydrogen. Several sulfonamides and alkyl sulfamates were explored, with the propylsulfamate providing the best combination of in vitro potency, especially for ETB antagonism, and in vivo efficacy.Related product price
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$37-1802
Suppliers and manufacturers
Seasons Biotechnology Co., Ltd.
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Shanghai Yingrui Biopharma Co., Ltd.
ATK CHEMICAL COMPANY LIMITED
