PF 543
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- $25 - $2395.3
- Product name: PF 543
- CAS: 1415562-82-1
- MF: C27H31NO4S
- MW: 465.6
- EINECS:
- MDL Number:MFCD23098794
- Synonyms:PF 543;PF543;PF-543;PF543/PF-543;(2R)-1-[[4-[[3-Methyl-5-[(phenylsulfonyl)Methyl]phenoxy]Methyl]phenyl]Methyl]-2-pyrrolidineMethanol;2-PyrrolidineMethanol, 1-[[4-[[3-Methyl-5-[(phenylsulfonyl)Methyl]phenoxy]Methyl]phenyl]Methyl]-, (2R)-;CS-745;PF-543(freebase)
24 prices
Selected condition:
Brand
- AK Scientific
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- Crysdot
- DC Chemicals
- Sigma-Aldrich
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 10mM(in 1mL DMSO)
- 50mg
- 100mg
- 200mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberX5812
- Product descriptionPF543
- Packaging10mg
- Price$302
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3717
- Product descriptionPF-543
- Packaging10mM(in 1mL DMSO)
- Price$105
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3717
- Product descriptionPF-543
- Packaging5mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3717
- Product descriptionPF-543
- Packaging10mg
- Price$195
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3717
- Product descriptionPF-543
- Packaging50mg
- Price$700
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3717
- Product descriptionPF-543
- Packaging200mg
- Price$1800
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146090
- Product descriptionPF-543 >98%
- Packaging100mg
- Price$615.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146090
- Product descriptionPF-543 >98%
- Packaging250mg
- Price$1208.7
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146090
- Product descriptionPF-543 >98%
- Packaging1g
- Price$2395.3
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17034
- Product descriptionPF-543 ≥98%
- Packaging1mg
- Price$25
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17034
- Product descriptionPF-543 ≥98%
- Packaging5mg
- Price$81
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17034
- Product descriptionPF-543 ≥98%
- Packaging10mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17034
- Product descriptionPF-543 ≥98%
- Packaging25mg
- Price$313
- Updated2021-12-16
- Buy
- ManufacturerChemenu
- Product numberCM197335
- Product description(R)-(1-(4-((3-methyl-5-((phenylsulfonyl)methyl)phenoxy)methyl)benzyl)pyrrolidin-2-yl)methanol 98%
- Packaging10mg
- Price$241
- Updated2021-12-16
- Buy
- ManufacturerChemenu
- Product numberCM197335
- Product description(R)-(1-(4-((3-methyl-5-((phenylsulfonyl)methyl)phenoxy)methyl)benzyl)pyrrolidin-2-yl)methanol 98%
- Packaging50mg
- Price$650
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003574
- Product descriptionPF-543 98+%
- Packaging5mg
- Price$135
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AK Scientific | X5812 | PF543 | 10mg | $302 | 2021-12-16 | Buy |
ApexBio Technology | A3717 | PF-543 | 10mM(in 1mL DMSO) | $105 | 2021-12-16 | Buy |
ApexBio Technology | A3717 | PF-543 | 5mg | $110 | 2021-12-16 | Buy |
ApexBio Technology | A3717 | PF-543 | 10mg | $195 | 2021-12-16 | Buy |
ApexBio Technology | A3717 | PF-543 | 50mg | $700 | 2021-12-16 | Buy |
ApexBio Technology | A3717 | PF-543 | 200mg | $1800 | 2021-12-16 | Buy |
Biorbyt Ltd | orb146090 | PF-543 >98% | 100mg | $615.4 | 2021-12-16 | Buy |
Biorbyt Ltd | orb146090 | PF-543 >98% | 250mg | $1208.7 | 2021-12-16 | Buy |
Biorbyt Ltd | orb146090 | PF-543 >98% | 1g | $2395.3 | 2021-12-16 | Buy |
Cayman Chemical | 17034 | PF-543 ≥98% | 1mg | $25 | 2021-12-16 | Buy |
Cayman Chemical | 17034 | PF-543 ≥98% | 5mg | $81 | 2021-12-16 | Buy |
Cayman Chemical | 17034 | PF-543 ≥98% | 10mg | $150 | 2021-12-16 | Buy |
Cayman Chemical | 17034 | PF-543 ≥98% | 25mg | $313 | 2021-12-16 | Buy |
Chemenu | CM197335 | (R)-(1-(4-((3-methyl-5-((phenylsulfonyl)methyl)phenoxy)methyl)benzyl)pyrrolidin-2-yl)methanol 98% | 10mg | $241 | 2021-12-16 | Buy |
Chemenu | CM197335 | (R)-(1-(4-((3-methyl-5-((phenylsulfonyl)methyl)phenoxy)methyl)benzyl)pyrrolidin-2-yl)methanol 98% | 50mg | $650 | 2021-12-16 | Buy |
Crysdot | CD31003574 | PF-543 98+% | 5mg | $135 | 2021-12-16 | Buy |
Properties
Boiling point :666.0±55.0 °C(Predicted)
Density :1.224±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :≥23.3 mg/mL in DMSO; insoluble in H2O; ≥51 mg/mL in EtOH with gentle warming and ultrasonic
pka :14.77±0.10(Predicted)
form :powder
color :white to light brown
Density :1.224±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :≥23.3 mg/mL in DMSO; insoluble in H2O; ≥51 mg/mL in EtOH with gentle warming and ultrasonic
pka :14.77±0.10(Predicted)
form :powder
color :white to light brown
Safety Information
Symbol(GHS): |
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Description
PF-543 is a potent inhibitor of sphingosine kinase 1 (SK1; IC50 = 2-3.6 nM) that less effectively inhibits SK2 (IC50 = 356 nM). It does not significantly block the activity of other protein and lipid kinases, or bind sphingosine-1-phosphate receptors, when tested at a concentration of 10 μM. PF-543 prevents the phosphorylation of sphingosine in cancer cells and in whole blood (EC50s = 8.4 and 27 nM, respectively). Through its effects on SK1, PF-543 prevents sickling, hemolysis, and inflammation in sickling cell disease transgenic mice. Unlike inhibitors that are selective for SK2, PF-543 does not impair DNA synthesis in human pulmonary arterial smooth muscle cells.More related product prices
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