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ChemicalBook >> CAS DataBase List >> trans-EKODE-(E)-Ib

trans-EKODE-(E)-Ib

trans-EKODE-(E)-Ib price.
  • $45 - $758
  • Product name: trans-EKODE-(E)-Ib
  • CAS: 478931-82-7
  • MF: C18H30O4
  • MW: 310.43
  • EINECS:
  • MDL Number:MFCD18427923
  • Synonyms:trans-EKODE-(E)-Ib;trans-EKODE-(E)-Ib Exclusive;9-oxo-11-(3-pentyl-2-oxiranyl)-10(E)-undecenoic acid;12,13-epoxy-9-Oxo-10(E)-Octadecenoic Acid;10-Undecenoic acid, 9-oxo-11-(3-pentyl-2-oxiranyl)-, (10E)-
5 prices
Selected condition:
Brand
  • Cayman Chemical
  • TRC
Package
  • 25μg
  • 50μg
  • 100μg
  • 500μg
  • ManufacturerCayman Chemical
  • Product number10004224
  • Product descriptiontrans-EKODE-(E)-Ib ≥98%
  • Packaging25μg
  • Price$49
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10004224
  • Product descriptiontrans-EKODE-(E)-Ib ≥98%
  • Packaging50μg
  • Price$92
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10004224
  • Product descriptiontrans-EKODE-(E)-Ib ≥98%
  • Packaging100μg
  • Price$172
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10004224
  • Product descriptiontrans-EKODE-(E)-Ib ≥98%
  • Packaging500μg
  • Price$758
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberE975108
  • Product description(10E)-9-Oxo-11-(3-pentyl-2-oxiranyl)-10-undecenoicAcid
  • Packaging25μg
  • Price$45
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Cayman Chemical 10004224 trans-EKODE-(E)-Ib ≥98% 25μg $49 2024-03-01 Buy
Cayman Chemical 10004224 trans-EKODE-(E)-Ib ≥98% 50μg $92 2024-03-01 Buy
Cayman Chemical 10004224 trans-EKODE-(E)-Ib ≥98% 100μg $172 2024-03-01 Buy
Cayman Chemical 10004224 trans-EKODE-(E)-Ib ≥98% 500μg $758 2024-03-01 Buy
TRC E975108 (10E)-9-Oxo-11-(3-pentyl-2-oxiranyl)-10-undecenoicAcid 25μg $45 2021-12-16 Buy

Properties

Boiling point :476.5±30.0 °C(Predicted)
Density :1.066±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): .5 mg/ml
pka :4.77±0.10(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242 Use only non-sparking tools.
P243 Take precautionary measures against static discharge.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P370+P378 In case of fire: Use … for extinction.
P403+P235 Store in a well-ventilated place. Keep cool.
P501 Dispose of contents/container to..…

Description

During oxidative stress, the abundant unsaturated fatty acid linoleic acid undergoes lipid peroxidation to produce α,β-unsaturated epoxy-keto-octadecenoic acids (EKODEs). Nonenzymatic autooxidation of linoleic acid generates six major EKODE isomers, which differ from one another in the positioning and the orientation of the epoxy group relative to the keto moiety. trans-EKODE-(E)-Ib is a biologically active peroxidation product of linoleic acid that is characterized, structurally, by having a trans carbon-carbon double bond between the 9-keto and 12,13-epoxy groups. It activates an antioxidant response element (ARE) in neuronal cells and induces the expression of ARE-regulated cytoprotective genes like NQO1. This EKODE also stimulates the synthesis of aldosterone and corticosterone in adrenal cells when supplied at 1-5 μM. This effect appears to be mediated by a rise in intracellular calcium.