UNC0646
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- $48 - $3728.1
- Product name: UNC0646
- CAS: 1320288-17-2
- MF: C36H59N7O2
- MW: 621.9
- EINECS:
- MDL Number:MFCD22378486
- Synonyms:UNC0646;N-(1-cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-Methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-aMine;UNC0646/UNC-0646;N-(1-Cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine;N-(1-Cyclohexyl-4-piperidinyl)-2-(4-isopropyl-1,4-diazepan-1-yl)- 6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine;(1-CYCLOHEXYL-PIPERIDIN-4-YL)-[2-(4-ISOPROPYL-[1,4]DIAZEPAN-1-YL)-6-METHOXY-7-(3-PIPERIDIN-1-YL-PROPOXY)-QUINAZOLIN-4-YL]-AMINE;UNC 0646;UNC0646;UNC-0646;CS-792
32 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- ApexBio Technology
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 5mg
- 50
- 1mg
- 10
- 10mg
- 25mg
- 2x25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number4143AH
- Product descriptionN-(1-Cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine
- Packaging10mg
- Price$170
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number4143AH
- Product descriptionN-(1-Cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine
- Packaging50mg
- Price$612
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA880677
- Product descriptionUNC0646 98+%
- Packaging5mg
- Price$66
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA880677
- Product descriptionUNC0646 98+%
- Packaging10mg
- Price$112
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA880677
- Product descriptionUNC0646 98+%
- Packaging25mg
- Price$190
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4504
- Product descriptionUNC0646
- Packaging10mg
- Price$92
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1840
- Product descriptionUNC0646 99%
- Packaging2x25mg
- Price$638
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146212
- Product descriptionUNC0646 >98%
- Packaging100mg
- Price$986
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146212
- Product descriptionUNC0646 >98%
- Packaging250mg
- Price$1949.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146212
- Product descriptionUNC0646 >98%
- Packaging1g
- Price$3728.1
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number11085
- Product descriptionUNC0646 ≥95%
- Packaging1mg
- Price$48
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number11085
- Product descriptionUNC0646 ≥95%
- Packaging5mg
- Price$117
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number11085
- Product descriptionUNC0646 ≥95%
- Packaging10mg
- Price$210
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number11085
- Product descriptionUNC0646 ≥95%
- Packaging50mg
- Price$936
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM295279
- Product descriptionN-(1-Cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine 98%
- Packaging50mg
- Price$230
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-2122
- Product descriptionUNC0646 99.82%
- Packaging5mg
- Price$72
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 4143AH | N-(1-Cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine | 10mg | $170 | 2021-12-16 | Buy |
| AK Scientific | 4143AH | N-(1-Cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine | 50mg | $612 | 2021-12-16 | Buy |
| Ambeed | A880677 | UNC0646 98+% | 5mg | $66 | 2021-12-16 | Buy |
| Ambeed | A880677 | UNC0646 98+% | 10mg | $112 | 2021-12-16 | Buy |
| Ambeed | A880677 | UNC0646 98+% | 25mg | $190 | 2021-12-16 | Buy |
| ApexBio Technology | A4504 | UNC0646 | 10mg | $92 | 2021-12-16 | Buy |
| Axon Medchem | Axon1840 | UNC0646 99% | 2x25mg | $638 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146212 | UNC0646 >98% | 100mg | $986 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146212 | UNC0646 >98% | 250mg | $1949.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146212 | UNC0646 >98% | 1g | $3728.1 | 2021-12-16 | Buy |
| Cayman Chemical | 11085 | UNC0646 ≥95% | 1mg | $48 | 2024-03-01 | Buy |
| Cayman Chemical | 11085 | UNC0646 ≥95% | 5mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 11085 | UNC0646 ≥95% | 10mg | $210 | 2024-03-01 | Buy |
| Cayman Chemical | 11085 | UNC0646 ≥95% | 50mg | $936 | 2024-03-01 | Buy |
| Chemenu | CM295279 | N-(1-Cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine 98% | 50mg | $230 | 2021-12-16 | Buy |
| ChemScene | CS-2122 | UNC0646 99.82% | 5mg | $72 | 2021-12-16 | Buy |
Properties
Boiling point :754.6±70.0 °C(Predicted)
Density :1.128±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,2-8°C
solubility :DMSO: soluble2mg/mL, clear (warmed)
pka :9.34±0.70(Predicted)
form :powder
color :white to beige
Density :1.128±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,2-8°C
solubility :DMSO: soluble2mg/mL, clear (warmed)
pka :9.34±0.70(Predicted)
form :powder
color :white to beige
Safety Information
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Description
G9a and G9a-like protein (GLP) are euchromatic histone-lysine methyltransferases (EHMT2 and EHMT1, respectively) that can heterodimerize with each other to methylate several proteins in addition to histone H3. UNC0646 is a potent and selective inhibitor of G9a and GLP activities in vitro (IC50s = 6 and 15 nM, respectively) and G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC50 = 26 nM). It is highly selective for G9a/GLP over several other protein lysine and arginine methyltransferases. UNC0646 potently inhibits G9a/GLP activity in a variety of cancer cell lines as well as in the human fetal lung IMR-90 line. This compound selectively targets the corepressor function of G9a without affecting its ability to act as a coactivator with glucocorticoid receptor.Related product price
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