CGP7930
- ¥56000 - ¥232000
- 化学名: CGP7930
- 英語名: 3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-B,B-DIMETHYL-BENZENEPROPANOL
- 別名:CGP7930
- CAS番号: 57717-80-3
- 分子式: C19H32O2
- 分子量: 292.46
- EINECS:
- MDL Number:MFCD04040028
2物価
選択条件:
ブランド
- 富士フイルム和光純薬株式会社(wako)
パッケージ
- 10mg
- 50mg
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01TOC1513
- 製品説明CGP7930
- 英語製品説明CGP 7930
- 包装単位10mg
- 価格¥56000
- 更新しました2024-03-01
- 購入
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01TOC1513
- 製品説明CGP7930
- 英語製品説明CGP 7930
- 包装単位50mg
- 価格¥232000
- 更新しました2024-03-01
- 購入
生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
---|---|---|---|---|---|---|
富士フイルム和光純薬株式会社(wako) | W01TOC1513 | CGP7930 CGP 7930 |
10mg | ¥56000 | 2024-03-01 | 購入 |
富士フイルム和光純薬株式会社(wako) | W01TOC1513 | CGP7930 CGP 7930 |
50mg | ¥232000 | 2024-03-01 | 購入 |
プロパティ
貯蔵温度 :Desiccate at RT
溶解性 :DMSO: 22 mg/mL, soluble
外見 :solid
色 :white
溶解性 :DMSO: 22 mg/mL, soluble
外見 :solid
色 :white
安全情報
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説明
CGP 7930 is a positive allosteric modulator of GABAB receptors. It enhances GABA binding with a maximal effect of 143% compared to a GABA-only control in CHO cells membranes expressing the GABAB(1b/2) receptor and enhances GABA binding to rat cortical membranes when used at a concentration of 30 μM. It is selective for GABA binding to heterodimeric GABAB(1b/2) over monomeric GABAB(1b) receptors. CGP 7930 potentiates the efficacy of the GABAB receptor agonist baclofen in decreasing the spontaneous firing rate of dopaminergic neurons in the rat ventral tegmental area (VTA) in vitro (EC50 = 0.27 μM). It also potentiates the sedative-reducing effects induced by the GABAB receptor agonists baclofen and γ-hydroxybutyric acid (GHB) in rats when administered at doses ranging from 10 to 170 mg/kg, effects that can be blocked by the GABAB receptor antagonist SCH 50911. CGP 7930 reduces self-administration of nicotine, alcohol, and cocaine in rodent models. It suppresses the acquisition of alcohol drinking behavior in alcohol-naïve Sardinian alcohol-preferring rats over a five-day period when administered at doses ranging from 25 to 100 mg/kg and transiently reduces the maintenance of alcohol drinking behavior in alcohol-experienced rats at a dose of 100 mg/kg.関連製品価格
関連商品価格
- CGP7930
¥56000-232000 - 2,2-ジメチル-3-(3-トリル)プロパン-1-オール
¥6600-25000
供給者とメーカー
TargetMol Chemicals Inc.
Aladdin Scientific
3B Pharmachem (Wuhan) International Co.,Ltd.
EMMX Biotechnology LLC
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
MedBioPharmaceutical Technology Inc
Changzhou Furuisi Biotechnology Co., Ltd
Shanghai Universal Biotech Co.,Ltd
TargetMol Chemicals Inc.
Nantong QuanYi Biotechnology Co., Ltd