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BAY 58-2667 hydrochloride

 price.
  • ¥49300 - ¥159000
  • 化学名:
  • 英語名: BAY 58-2667 hydrochloride
  • 別名:
  • CAS番号: 646995-35-9
  • 分子式: C36H40ClNO5
  • 分子量: 602.17
  • EINECS:
  • MDL Number:MFCD28127267
2物価
選択条件:
ブランド
  • Sigma-Aldrich Japan
パッケージ
  • 5mg
  • 25mg
  • 生産者Sigma-Aldrich Japan
  • 製品番号SML1532
  • 製品説明 ≥98% (HPLC)
  • 英語製品説明Cinaciguat hydrochloride ≥98% (HPLC)
  • 包装単位5mg
  • 価格¥49300
  • 更新しました2024-03-01
  • 購入
  • 生産者Sigma-Aldrich Japan
  • 製品番号SML1532
  • 製品説明 ≥98% (HPLC)
  • 英語製品説明Cinaciguat hydrochloride ≥98% (HPLC)
  • 包装単位25mg
  • 価格¥159000
  • 更新しました2024-03-01
  • 購入
生産者 製品番号 製品説明 包装単位 価格 更新時間 購入
Sigma-Aldrich Japan SML1532 ≥98% (HPLC)
Cinaciguat hydrochloride ≥98% (HPLC)
5mg ¥49300 2024-03-01 購入
Sigma-Aldrich Japan SML1532 ≥98% (HPLC)
Cinaciguat hydrochloride ≥98% (HPLC)
25mg ¥159000 2024-03-01 購入

プロパティ

貯蔵温度  :-20°C
溶解性 :DMSO:66.74(Max Conc. mg/mL);110.83(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);0.83(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);49.82(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);8.3(Max Conc. mM) 外見  :powder
色 :white to beige

安全情報

絵表示(GHS):
注意喚起語:
危険有害性情報:
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
注意書き:

説明

Soluble guanylate cyclase (sGC) is the primary cellular receptor for NO. NO binds and activates a heme group in sGC, initiating the conversion of GTP to the second messenger cGMP. cGMP subsequently mediates a number of signaling cascades leading to vasorelaxation and inhibiting smooth muscle proliferation, leukocyte recruitment, and platelet aggregation. Oxidation of the heme results in its dissociation from sGC and an impairment of NO signaling, which has been linked to hypertension, hyperlidemia, cardiovascular disease, and diabetes. Cinaciguat is an activator of sGC that binds to a regulatory site, resulting in activation in an NO-independent manner (Kd = 3.2 nM). It activates the enzyme even if it has been oxidized or rendered heme deficient. In animals, cinaciguat has been shown to reduce hypertension, limit cardiomyocyte hypertrophy, protect against ischemia/reperfusion injury, and reduce morbidity and mortality in response to endotoxic shock.