COLIVELIN
1物価
選択条件:
ブランド
- 富士フイルム和光純薬株式会社(wako)
パッケージ
- 500μg
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01TOC3945
- 製品説明
- 英語製品説明Colivelin
- 包装単位500μg
- 価格¥111000
- 更新しました2024-03-01
- 購入
生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
---|---|---|---|---|---|---|
富士フイルム和光純薬株式会社(wako) | W01TOC3945 | Colivelin |
500μg | ¥111000 | 2024-03-01 | 購入 |
プロパティ
比重(密度) :1.42±0.1 g/cm3(Predicted)
貯蔵温度 :Store at -20°C
溶解性 :insoluble in DMSO; insoluble in EtOH; ≥15 mg/mL in H2O
外見 :solid
色 :White
水溶解度 :Soluble to 1 mg/ml in 20% ethanol / water
貯蔵温度 :Store at -20°C
溶解性 :insoluble in DMSO; insoluble in EtOH; ≥15 mg/mL in H2O
外見 :solid
色 :White
水溶解度 :Soluble to 1 mg/ml in 20% ethanol / water
安全情報
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説明
Colivelin is a potent synthetic peptide activator of STAT3 that has neuroprotective activity. It protects approximately 50 and 100% of mouse primary cortical neurons from cell death induced by amyloid β (1-43) (Aβ43) when used at concentrations of 10 and 100 fM, respectively. Colivelin protects against cell death induced by V642I-APP in a CaM kinase IV (CaMKIV) and STAT3-dependent manner. It increases STAT3 phosphorylation in vitro and in vivo, an effect that correlates with improvements in working memory. Colivelin (10 pmol every six days) rescues deficits in spatial working memory in a mouse model of Alzheimer’s disease induced by intracerebroventricular injection of Aβ25-35. It also improves motor performance and prolongs survival in a mouse model of amyotrophic lateral sclerosis (ALS).供給者とメーカー
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