コレセベラム塩酸塩
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- ¥12600 - ¥43000
- 化学名: コレセベラム塩酸塩
- 英語名: Colesevelam
- 別名:コレセベラム塩酸塩
- CAS番号: 182815-44-7
- 分子式: C31H66Cl2N4O
- 分子量: 581.8
- EINECS:806-925-3
- MDL Number:
2物価
選択条件:
ブランド
- 富士フイルム和光純薬株式会社(wako)
パッケージ
- 200mg
- 1g
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01W0103-2485
- 製品説明コレセベラム塩酸塩
- 英語製品説明Colesevelam Hydrochloride
- 包装単位200mg
- 価格¥12600
- 更新しました2021-03-23
- 購入
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01W0103-2485
- 製品説明コレセベラム塩酸塩
- 英語製品説明Colesevelam Hydrochloride
- 包装単位1g
- 価格¥43000
- 更新しました2020-09-21
- 購入
生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
---|---|---|---|---|---|---|
富士フイルム和光純薬株式会社(wako) | W01W0103-2485 | コレセベラム塩酸塩 Colesevelam Hydrochloride |
200mg | ¥12600 | 2021-03-23 | 購入 |
富士フイルム和光純薬株式会社(wako) | W01W0103-2485 | コレセベラム塩酸塩 Colesevelam Hydrochloride |
1g | ¥43000 | 2020-09-21 | 購入 |
プロパティ
貯蔵温度 :Store at -20°C
外見 :Solid
色 :White to light yellow
外見 :Solid
色 :White to light yellow
安全情報
絵表示(GHS): |
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注意喚起語: | Warning | ||||||||||||||||||||||||||||
危険有害性情報: |
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注意書き: |
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説明
Colesevelam hydrochloride was launched as Welchol (formerly known as Cholestagel) in the US for the reduction of elevated levels of serum LDL cholesterol and accordingly, the decrease of the risk of vascular disease in patients with primary hypercholesterolemia. This orally administered cationic hydrogel is a non-absorbable, water-insoluble polymer of an hexanaminium chloride with N-(2-propenyl) decanamine, 2-propen-1-amine hydrochloride and chloromethyloxirane. It acts as a powerful bile acid sequestering agent, this binding and blockage of bile acids having the end result of compelling the removal of LDL cholesterol from the blood stream into the liver. In animals fed with a cholesterol-rich diet for several weeks, colesevelam demonstrated a good maintenance of low serum cholesterol levels, this activity being significantly greater when compared with cholestyramine. In several placebo-controlled studies, this agent decreased total cholesterol levels by 6 to 10% and LDL cholesterol levels by 9 to 20%. Combination therapy with the co-administration of a HMG-CoA reductase inhibitor (or statin) and colesevelam produced an additional reduction of 8-16% in LDL-cholesterol levels above that obtained with the statin alone. Due to its unique water-absorbing hydrogel formulation, this polymer is not absorbed at all from the GI tract, and thus, it is said to have a lower rate of side-effects (as the constipating effect) than the previously marketed bile acid sequestrants. Colesevelam hydrochloride may be used as a monotherapy or as a dual therapy with statins.関連商品価格
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