[LYS47]ヒルジン(HV2) ヒル由来
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- ¥34900 - ¥335000
- 化学名: [LYS47]ヒルジン(HV2) ヒル由来
- 英語名: HIRUDIN
- 別名:[LYS47]ヒルジン(HV2) ヒル由来;ヒルジン ヒル由来
- CAS番号: 8001-27-2
- 分子式: C287H440N80O113S7
- 分子量: 7043.4877
- EINECS:232-279-1
- MDL Number:MFCD00081692
6物価
選択条件:
ブランド
- Sigma-Aldrich Japan
パッケージ
- 100un
- 500un
- 1ea
- 100units
- 500units
- 生産者Sigma-Aldrich Japan
- 製品番号H7380
- 製品説明ヒルジン ヒル由来 lyophilized powder, 300-1,500?ATU/mg protein (ATU = antithrombin units)
- 英語製品説明Hirudin from leeches lyophilized powder, 300-1,500?ATU/mg protein (ATU = antithrombin units)
- 包装単位100un
- 価格¥34900
- 更新しました2018-12-25
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番号H0393
- 製品説明[Lys47]ヒルジン(HV2) ヒル由来
- 英語製品説明Hirudin
recombinant, expressed in unspecified host, ≥7,000?ATU/mg protein (ATU = antithrombin units) - 包装単位100un
- 価格¥69800
- 更新しました2018-12-25
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番号H0393
- 製品説明ヒルジン ヒル由来 recombinant, expressed in unspecified host, ≥7,000?ATU/mg protein (ATU = antithrombin units)
- 英語製品説明Hirudin recombinant, expressed in unspecified host, ≥7,000?ATU/mg protein (ATU = antithrombin units)
- 包装単位100units
- 価格¥96200
- 更新しました2024-03-01
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番号H0393
- 製品説明[Lys47]ヒルジン(HV2) ヒル由来
- 英語製品説明Hirudin
recombinant, expressed in unspecified host, ≥7,000?ATU/mg protein (ATU = antithrombin units) - 包装単位500un
- 価格¥241300
- 更新しました2018-12-25
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番号94581
- 製品説明 lyophilized powder, white, >1500?U/vial
- 英語製品説明Hirudin recombinant from yeast lyophilized powder, white, >1500?U/vial
- 包装単位1ea
- 価格¥296000
- 更新しました2024-03-01
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番号H0393
- 製品説明ヒルジン ヒル由来 recombinant, expressed in unspecified host, ≥7,000?ATU/mg protein (ATU = antithrombin units)
- 英語製品説明Hirudin recombinant, expressed in unspecified host, ≥7,000?ATU/mg protein (ATU = antithrombin units)
- 包装単位500units
- 価格¥335000
- 更新しました2024-03-01
- 購入
生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
---|---|---|---|---|---|---|
Sigma-Aldrich Japan | H7380 | ヒルジン ヒル由来 lyophilized powder, 300-1,500?ATU/mg protein (ATU = antithrombin units) Hirudin from leeches lyophilized powder, 300-1,500?ATU/mg protein (ATU = antithrombin units) |
100un | ¥34900 | 2018-12-25 | 購入 |
Sigma-Aldrich Japan | H0393 | [Lys47]ヒルジン(HV2) ヒル由来 Hirudin recombinant, expressed in unspecified host, ≥7,000?ATU/mg protein (ATU = antithrombin units) |
100un | ¥69800 | 2018-12-25 | 購入 |
Sigma-Aldrich Japan | H0393 | ヒルジン ヒル由来 recombinant, expressed in unspecified host, ≥7,000?ATU/mg protein (ATU = antithrombin units) Hirudin recombinant, expressed in unspecified host, ≥7,000?ATU/mg protein (ATU = antithrombin units) |
100units | ¥96200 | 2024-03-01 | 購入 |
Sigma-Aldrich Japan | H0393 | [Lys47]ヒルジン(HV2) ヒル由来 Hirudin recombinant, expressed in unspecified host, ≥7,000?ATU/mg protein (ATU = antithrombin units) |
500un | ¥241300 | 2018-12-25 | 購入 |
Sigma-Aldrich Japan | 94581 | lyophilized powder, white, >1500?U/vial Hirudin recombinant from yeast lyophilized powder, white, >1500?U/vial |
1ea | ¥296000 | 2024-03-01 | 購入 |
Sigma-Aldrich Japan | H0393 | ヒルジン ヒル由来 recombinant, expressed in unspecified host, ≥7,000?ATU/mg protein (ATU = antithrombin units) Hirudin recombinant, expressed in unspecified host, ≥7,000?ATU/mg protein (ATU = antithrombin units) |
500units | ¥335000 | 2024-03-01 | 購入 |
プロパティ
貯蔵温度 :2-8°C
外見 :lyophilized powder
色 :white
Merck :13,4737
外見 :lyophilized powder
色 :white
Merck :13,4737
安全情報
絵表示(GHS): |
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説明
Refludan was launched in Germany for heparin-associated thrombocytopenia. Originally isolated from the saliva of leeches (Hirudo medicinalis), the gene for recombinant hirudin was synthesized and expressed in Saccharomyces cerevisiae. The isolated protein is 65 amino acids differing from the native protein by the first two amino acids (Leu1 and Thr2) and Tyr63 is not sulfated, while it does retain the three disulfide bonds. Refludan is a potent, specific and almost irreversible inhibitor of thrombin with which it forms a 1:1 complex. The N-terminal domain binds to the active catalytic site of thrombin, while the C-terminal end binds to the anion binding exosite (fibrinogen binding cleft). It has several advantages over heparin: it can inhibit thrombin bound to extracellular matrices, does not require antithrombin Ⅲ as a cofactor, is not inhibited by activated platelet nor increases platelet activity, and is a pure, single compound with a single mechanism of action. It is useful for myocardial infarcts, unstable angia and cardiovascular events. Heparin treatment can be inhibited by platelets activated by the Fc fragment of antibodies developed to the antigen of heparin-platelet factor 4. A corresponding inactivation of Refuldan is not known.関連商品価格
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