P-5091
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4物価
選択条件：
ブランド
- 富士フイルム和光純薬株式会社(wako)
- Sigma-Aldrich Japan
パッケージ
- 5mg
- 10mg
- 25mg
- 50mg
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01TOC4733
- 製品説明
- 英語製品説明P005091
- 包装単位10mg
- 価格￥46000
- 更新しました2021-03-23
- 購入
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01TOC4733
- 製品説明
- 英語製品説明P005091
- 包装単位50mg
- 価格￥206000
- 更新しました2021-03-23
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番号SML0770
- 製品説明 ≥98% (HPLC)
- 英語製品説明P5091 ≥98% (HPLC)
- 包装単位25mg
- 価格￥79100
- 更新しました2024-03-01
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番号SML0770
- 製品説明 ≥98% (HPLC)
- 英語製品説明P5091 ≥98% (HPLC)
- 包装単位5mg
- 価格￥17000
- 更新しました2024-03-01
- 購入
| 生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
|---|---|---|---|---|---|---|
| 富士フイルム和光純薬株式会社(wako) | W01TOC4733 | P005091 |
10mg | ￥46000 | 2021-03-23 | 購入 |
| 富士フイルム和光純薬株式会社(wako) | W01TOC4733 | P005091 |
50mg | ￥206000 | 2021-03-23 | 購入 |
| Sigma-Aldrich Japan | SML0770 | ≥98% (HPLC) P5091 ≥98% (HPLC) |
25mg | ￥79100 | 2024-03-01 | 購入 |
| Sigma-Aldrich Japan | SML0770 | ≥98% (HPLC) P5091 ≥98% (HPLC) |
5mg | ￥17000 | 2024-03-01 | 購入 |
プロパティ
沸点 :452.4±45.0 °C(Predicted)
比重(密度) :1.60±0.1 g/cm3(Predicted)
貯蔵温度 :2-8°C
溶解性 :DMSO: soluble10mg/mL, clear
外見 :powder
色 :light yellow to dark yellow
安定性： :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
比重(密度) :1.60±0.1 g/cm3(Predicted)
貯蔵温度 :2-8°C
溶解性 :DMSO: soluble10mg/mL, clear
外見 :powder
色 :light yellow to dark yellow
安定性： :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
安全情報
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| 注意喚起語: | Danger | |||||||||||||||||||||
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説明
Ubiquitin-specific proteases (USP/UBP) remove ubiquitin from proteins, sparing them from degradation by the proteasome. USP7 is a cysteine protease associated with prostate cancer that selectively deubiquitylates HDM2, the ubiquitin E3 ligase for the tumor suppressor p53. P005091 is a trisubstituted thiophene that inhibits USP7 and the closely related USP47 (EC50s = 4.2 and 4.3 μM, respectively) with little activity against other classes of proteases, including caspases, cathepsins, calpain, metalloproteases, and serine proteases (EC50s = > 100 μM). P005091 has been shown to accelerate the degradation of the USP7 substrate HDM2 in several multiple myeloma cell lines (EC50 = 11 μM) and to inhibit the growth of HCT-116 human colorectal cancer cells (EC50 = 11 μM) synergistically with doxorubicin, etoposide, or mechlorethamine. In vivo, 10 mg/kg P005091 prolongs survival and reduces tumor growth in mice bearing human multiple myeloma and B cell leukemia xenografts.関連商品価格
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