PF429242 dihydrochloride
|
2物価
選択条件：
ブランド
- 富士フイルム和光純薬株式会社(wako)
パッケージ
- 10mg
- 50mg
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01TOC3354
- 製品説明
- 英語製品説明PF 429242
- 包装単位10mg
- 価格￥95000
- 更新しました2023-06-01
- 購入
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01TOC3354
- 製品説明
- 英語製品説明PF 429242
- 包装単位50mg
- 価格￥376000
- 更新しました2023-06-01
- 購入
| 生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
|---|---|---|---|---|---|---|
| 富士フイルム和光純薬株式会社(wako) | W01TOC3354 | PF 429242 |
10mg | ￥95000 | 2023-06-01 | 購入 |
| 富士フイルム和光純薬株式会社(wako) | W01TOC3354 | PF 429242 |
50mg | ￥376000 | 2023-06-01 | 購入 |
プロパティ
貯蔵温度 :Store at -20°C
溶解性 :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
外見 :A crystalline solid
色 :White to light brown
溶解性 :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
外見 :A crystalline solid
色 :White to light brown
安全情報
| 絵表示(GHS): |
  
|
|||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 注意喚起語: | Danger | |||||||||||||||||||||||||||||||||||||||||||||||||
| 危険有害性情報: |
|
|||||||||||||||||||||||||||||||||||||||||||||||||
| 注意書き: |
|
説明
PF-429242 is an inhibitor of site-1 protease with an IC50 value of 170 nM for human recombinant site-1 protease. It is selective for site-1 protease over trypsin, elastase, proteinase K, plasmin, kallikren, factor XIa, thrombin, and furin at concentrations up to 100 μM. PF-429242 completely inhibits proteolytic processing and nuclear translocation of sterol regulatory element-binding protein (SREBP) in HepG2 cells at a concentration of 10 μM. It also reduces expression of HMG-CoA synthase and fatty acid synthase (EC50s = 0.3 and 2 μM, respectively) and inhibits cholesterol synthesis (EC50 = 600 nM) in HepG2 cells and reduces cholesterol and fatty acid synthesis in CD-1 mice. PF-429242 inhibits replication of dengue virus serotypes 1-4 in infected HeLa cells. It also reduces growth of T98G, U87-MG, and A172 glioblastoma cells (IC50s = 0.32, 15.2, and 27.6 μM, respectively).供給者とメーカー
TargetMol Chemicals Inc.
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
LEAP CHEM CO., LTD.
Aladdin Scientific
Shanghai EFE Biological Technology Co., Ltd.
Beijing Solarbio Science & Tecnology Co., Ltd.
Chuzhou KeMail Chemical Technology Co., Ltd
Shanghai Hongye Biotechnology Co. Ltd
Fan De(Beijing) Biotechnology Co., Ltd.