(R)-Butaprost, free acid
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3物価
選択条件:
ブランド
- 富士フイルム和光純薬株式会社(wako)
パッケージ
- 1mg
- 5mg
- 10mg
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01CAY10006045
- 製品説明
- 英語製品説明(R)-Butaprost (free acid)
- 包装単位1mg
- 価格¥45100
- 更新しました2024-03-01
- 購入
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01CAY10006045
- 製品説明
- 英語製品説明(R)-Butaprost (free acid)
- 包装単位5mg
- 価格¥187900
- 更新しました2024-03-01
- 購入
- 生産者富士フイルム和光純薬株式会社(wako)
- 製品番号W01CAY10006045
- 製品説明
- 英語製品説明(R)-Butaprost (free acid)
- 包装単位10mg
- 価格¥328200
- 更新しました2024-03-01
- 購入
生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
---|---|---|---|---|---|---|
富士フイルム和光純薬株式会社(wako) | W01CAY10006045 | (R)-Butaprost (free acid) |
1mg | ¥45100 | 2024-03-01 | 購入 |
富士フイルム和光純薬株式会社(wako) | W01CAY10006045 | (R)-Butaprost (free acid) |
5mg | ¥187900 | 2024-03-01 | 購入 |
富士フイルム和光純薬株式会社(wako) | W01CAY10006045 | (R)-Butaprost (free acid) |
10mg | ¥328200 | 2024-03-01 | 購入 |
プロパティ
沸点 :565.7±50.0 °C(Predicted)
比重(密度) :1.145±0.06 g/cm3(Predicted)
溶解性 :DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): .1 mg/ml
酸解離定数(Pka) :4.77±0.10(Predicted)
比重(密度) :1.145±0.06 g/cm3(Predicted)
溶解性 :DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): .1 mg/ml
酸解離定数(Pka) :4.77±0.10(Predicted)
安全情報
絵表示(GHS): |
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注意書き: |
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説明
Butaprost is a structural analog of prostaglandin E2 (PGE2) with good selectivity for the EP2 receptor subtype. Butaprost has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells . Serious confusion as to the structure of butaprost was generated by Gardiner in 1986,2 when he reported that the epimer of butaprost showing this selective activity was the C-16 (R)-epimer. In order to increase the binding affinity of (R)-butaprost for prostanoid receptors, we removed the methyl ester of (R)-butaprost and re-established the natural C-1 carboxylic acid. Prostaglandin free acids generally bind to their cognate receptors with 10 to 100 times the affinity of the corresponding ester derivative. The pharmacology of (R)-butaprost has not been carefully studied, but it is generally considered to be the less active C-16 epimer. (NOTE: In the Gardiner paper in the 1986 British Journal of Pharmacology, butaprost appears on page 46 where it is given the name TR 4979. The structure as drawn is incorrect, in that the author was using and referring to the more active C-16 epimer, which is actually 16(S). The structure on page 46 shows the structure as 16(R). It was not until the late 1990’s that careful studies both in the US and Japan correctly identified the actual configuration of C-16 in the compound called butaprost is 16(S).供給者とメーカー
Aladdin Scientific
BOC Sciences
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Shanghai EFE Biological Technology Co., Ltd.
Shanghai YuanYe Biotechnology Co., Ltd.
Shanghai Hongye Biotechnology Co. Ltd
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
MedBioPharmaceutical Technology Inc
TargetMol Chemicals Inc.
Hubei Danding Pharmaceutical Technology Co., Ltd