Unii-0789652qul
2物価
選択条件:
ブランド
- Sigma-Aldrich Japan
パッケージ
- 5mg
- 25mg
- 生産者Sigma-Aldrich Japan
- 製品番号Y1646
- 製品説明 ≥98% (HPLC)
- 英語製品説明YH439 ≥98% (HPLC)
- 包装単位5mg
- 価格¥32000
- 更新しました2024-03-01
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番号Y1646
- 製品説明 ≥98% (HPLC)
- 英語製品説明YH439 ≥98% (HPLC)
- 包装単位25mg
- 価格¥125600
- 更新しました2021-03-23
- 購入
生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
---|---|---|---|---|---|---|
Sigma-Aldrich Japan | Y1646 | ≥98% (HPLC) YH439 ≥98% (HPLC) |
5mg | ¥32000 | 2024-03-01 | 購入 |
Sigma-Aldrich Japan | Y1646 | ≥98% (HPLC) YH439 ≥98% (HPLC) |
25mg | ¥125600 | 2021-03-23 | 購入 |
プロパティ
比重(密度) :1.467±0.06 g/cm3(Predicted)
貯蔵温度 :2-8°C
溶解性 :DMSO: ≥5mg/mL
外見 :solid
酸解離定数(Pka) :4.89±0.70(Predicted)
色 :Light yellow to yellow
貯蔵温度 :2-8°C
溶解性 :DMSO: ≥5mg/mL
外見 :solid
酸解離定数(Pka) :4.89±0.70(Predicted)
色 :Light yellow to yellow
安全情報
絵表示(GHS): | ||||||||
---|---|---|---|---|---|---|---|---|
注意喚起語: | ||||||||
危険有害性情報: |
|
|||||||
注意書き: |
|
説明
Mivotilate is an orally-active hepatoprotective agent introduced for the treatment of liver cirrhosis and hepatitis-B infection. It is a dithietanylidene malonate analogue of malotilate and is without the haemotological adverse effects associated with the latter. Mivotilate can be obtained by partial saponification of the corresponding diisopropylmalonate, conversion of the acid function into mixed anhydride then to the amide with an aminothiazole. It displays potent hepatoprotective activity in rat and mice liver injury models by a mechanism involving the inactivation of Kupffer cells. Mivotilate was shown to exert multiple effects on the hepatic cytochrome P450 system, particularly to inhibit CYP2E1 expression and to up-regulate the CYP1A1 expression. The low oral bioavailability of Mivotilate in rats (F<0.22%) could be primarilly attributed to poor absorption and considerable hepatic and gastrointestinal first-pass effects. Mivotilate prevents mutagenesis caused by agents such as benzo[a]pyrene and reduces skin tumors induced by these agents.供給者とメーカー
TargetMol Chemicals Inc.
Jilin Chinese Academy of Sciences-yanshen Technology
Aladdin Scientific
Beijing HuaMeiHuLiBiological Chemical
Fan De(Beijing) Biotechnology Co., Ltd.
Energy Chemical
Beijing Jin Ming Biotechnology Co., Ltd.
ChemeGen 中国
Kaifeng Mingren Pharmaceutical Co.,LTD
TargetMol Chemicals Inc.