(5Z,8Z,11Z,14Z)-N-(2-フルオロエチル)-2-メチル-5,8,11,14-イコサテトラエンアミド
- ¥33800 - ¥33800
- 化学名: (5Z,8Z,11Z,14Z)-N-(2-フルオロエチル)-2-メチル-5,8,11,14-イコサテトラエンアミド
- 英語名: O-689
- 別名:(5Z,8Z,11Z,14Z)-N-(2-フルオロエチル)-2-メチル-5,8,11,14-イコサテトラエンアミド;(5Z,8Z,11Z,14Z)-N-(2-フルオロエチル)-2-メチルイコサ-5,8,11,14-テトラエンアミド
- CAS番号: 166100-39-6
- 分子式: C23H38FNO
- 分子量: 363.55
- EINECS:200-578-6
- MDL Number:MFCD01862615
1物価
選択条件:
ブランド
- Sigma-Aldrich Japan
パッケージ
- 5mg
- 生産者Sigma-Aldrich Japan
- 製品番号M1438
- 製品説明 ≥95%, ethanol solution
- 英語製品説明(±)-2-Methylarachidonoyl-2′-fluoroethylamide ≥95%, ethanol solution
- 包装単位5mg
- 価格¥33800
- 更新しました2024-03-01
- 購入
生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
---|---|---|---|---|---|---|
Sigma-Aldrich Japan | M1438 | ≥95%, ethanol solution (±)-2-Methylarachidonoyl-2′-fluoroethylamide ≥95%, ethanol solution |
5mg | ¥33800 | 2024-03-01 | 購入 |
プロパティ
沸点 :503.6±50.0 °C(Predicted)
比重(密度) :0.921±0.06 g/cm3(Predicted)
闪点 :14 °C
貯蔵温度 :−20°C
溶解性 :DMF: >10 mg/ml; DMSO: >30 mg/ml; Ethanol: >100 mg/ml; Ethanol:PBS (1:2): 8.5 mg/ml; PBS (pH 7.2): <100 μg/ml
酸解離定数(Pka) :14.98±0.46(Predicted)
外見 :ethanol solution
比重(密度) :0.921±0.06 g/cm3(Predicted)
闪点 :14 °C
貯蔵温度 :−20°C
溶解性 :DMF: >10 mg/ml; DMSO: >30 mg/ml; Ethanol: >100 mg/ml; Ethanol:PBS (1:2): 8.5 mg/ml; PBS (pH 7.2): <100 μg/ml
酸解離定数(Pka) :14.98±0.46(Predicted)
外見 :ethanol solution
安全情報
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説明
(±)-2-Methyl arachidonoyl-2'-fluoroethylamide (2-Methyl-2'-fluoro AEA) is an analog of anandamide (AEA) in which the alcohol of the ethanolamide group has been removed and replaced with a fluorine atom. This substitution confers considerably increased binding affinity for the CB1 receptor (Ki = 5.7 nM in rat brain). It also confers additional selectivity, in that binding to CB2 is decreased relative to AEA. However, the in vivo activity of 2-fluoro AEA is enhanced much less than the binding affinity, because the analog remains a good substrate for FAAH and is rapidly hydrolyzed by this enzyme. 2-Methyl-2'-fluoro AEA is further modified by the addition of an α-methyl group at the C-2 position of arachidonic acid. This substitution confers enhanced metabolic stability. 2-Methyl-2'-fluoro AEA can fully substitute for Δ9-THC in animal self-administration tests, whereas AEA and 2-fluoro AEA cannot.関連商品価格
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