ReModelin
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2物価
選択条件：
ブランド
- Sigma-Aldrich Japan
パッケージ
- 5mg
- 25mg
- 生産者Sigma-Aldrich Japan
- 製品番号SML1112
- 製品説明 ≥98% (HPLC)
- 英語製品説明Remodelin hydrobromide ≥98% (HPLC)
- 包装単位5mg
- 価格￥22600
- 更新しました2024-03-01
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番号SML1112
- 製品説明リモデリン 臭化水素酸塩 ≥98% (HPLC)
- 英語製品説明Remodelin hydrobromide ≥98% (HPLC)
- 包装単位25mg
- 価格￥87800
- 更新しました2023-06-01
- 購入
| 生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
|---|---|---|---|---|---|---|
| Sigma-Aldrich Japan | SML1112 | ≥98% (HPLC) Remodelin hydrobromide ≥98% (HPLC) |
5mg | ￥22600 | 2024-03-01 | 購入 |
| Sigma-Aldrich Japan | SML1112 | リモデリン 臭化水素酸塩 ≥98% (HPLC) Remodelin hydrobromide ≥98% (HPLC) |
25mg | ￥87800 | 2023-06-01 | 購入 |
プロパティ
沸点 :498.9±47.0 °C(Predicted)
比重(密度) :1.31±0.1 g/cm3(Predicted)
貯蔵温度 :2-8°C
溶解性 :DMSO: soluble20mg/mL, clear
外見 :powder
酸解離定数(Pka) :14.40±0.20(Predicted)
色 :white to beige
安定性： :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
比重(密度) :1.31±0.1 g/cm3(Predicted)
貯蔵温度 :2-8°C
溶解性 :DMSO: soluble20mg/mL, clear
外見 :powder
酸解離定数(Pka) :14.40±0.20(Predicted)
色 :white to beige
安定性： :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
安全情報
| 絵表示(GHS): |
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| 注意喚起語: | Warning | ||||||||||||||
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説明
Progeria is a genetic disorder that results in the appearance of premature aging. Genetically, progeria is characterized by a mutation in lamin A, which results in misshapen cell nuclei and DNA damage. Remodelin is a 2-thiazolylhydrazone derivative that, at 10 μM, improves nuclear architecture, chromatin organization, and survival of both cells lacking lamin A and cells from patients with progeria. Remodelin is an inhibitor of N-acetyltransferase 10 (NAT10), which acetylates both histones and microtubules. Mutation of NAT10 mimics the effects of remodelin on nuclear morphology, suggesting that these effects of remodelin require NAT10. Remodelin also has cytotoxic effects against some species of the fungus Candida.関連商品価格
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