| | 58798-97-3 Basic information More.. |
| Product Name: | berninamycin A | | Synonyms: | berninamycin A;Berninamycin;BerninaMycin, U27810;Alaninamide, L-threonyl-2-[(1Z)-1-amino-1-propen-1-yl]-5-methyl-4-oxazolecarbonyl-2,3-didehydroalanyl-3-methyl-L-threonyl-2-(1-aminoethenyl)-5-methyl-4-oxazolecarbonyl-2,3-didehydroalanyl-6-[2-(1-aminoethenyl)-4-oxazolyl]-5-(4-carboxy-2-thiazolyl)-2-pyridinecarbonyl-2,3-didehydroalanyl-2,3-didehydro... | | CAS: | 58798-97-3 | | MF: | C51H51N15O15S | | MW: | 1146.11 | | EINECS: | | | Mol File: | 58798-97-3.mol |  |
Use
Berninamycin A is an antibiotic discovered in 1976 from a strain of Streptomyces. Berninamycin A is a macrocyclic "peptide" comprising atypical amino acids linked to thiazole and oxazoles. Chemically very complex, berninamycin A is an inducer of tipA, a gene that controls the bacterial transcription regulators, TipAL and TipAS, that are central to multidrug resistance. Berninamycin A is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.
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58798-97-3
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