| 634207-53-7 Basic information More.. |
Product Name: | 8-pCPT-2μ-O-Me-cAMP | Synonyms: | 8-pCPT-2'-O-Me-Cyclic AMP (sodium salt);8-(4-Chlorophenylthio)-2μ-O-methyladenosine 3μ,5μ-cyclic monophosphate hydrate monosodium;8-pCPT-2μ-O-Me-cAMP;8-(4-Chlorophenylthio)-2′-O-methyladenosine 3′,5′-cyclic monophosphate monosodium hydrate;8-pCPT-2’-O-Me-cAMP | CAS: | 634207-53-7 | MF: | C17H16ClN5NaO6PS | MW: | 507.82 | EINECS: | | Mol File: | 634207-53-7.mol | ![634207-53-7](/CAS/20181012/GIF/634207-53-7.gif) |
Use
]Exchange proteins activated by cAMP (Epacs) are guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2. 8-pCPT-2'-O-Me-cAMP is a super-activator of Epacs in that it dissociates GDP from Rap1 more strongly than the natural Epac agonist, cAMP. 8-pCPT-2'-O-Me-cAMP is strongly selective for Epac over the cAMP-activated kinase PKA. It does not discriminate between Epac1 and Epac2 and is used extensively to elucidate the roles of these Rap GEFs in cell function.[Cayman Chemical]
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634207-53-7
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