| | 1222780-33-7 Basic information More.. |
| Product Name: | TPPU | | Synonyms: | 1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea;N-[1-(1-Oxopropyl)-4-piperidinyl]-N′-[4-(trifluoromethoxy)phenyl]-urea;TPPU Exclusive;TPPU;CS-2462;Urea, N-[1-(1-oxopropyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]-;TPPU >=98% (HPLC);TPPU(CS-2462) | | CAS: | 1222780-33-7 | | MF: | C16H20F3N3O3 | | MW: | 359.34 | | EINECS: | | | Mol File: | 1222780-33-7.mol |  |
Use
Soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols. Inhibitors of sEH have anti-inflammatory, anti-hypertensive, neuroprotective, and cardioprotective effects. TPPU is a potent inhibitor of both human and mouse sEH (IC50 = 3.7 and 2.8 nM, respectively). The pharmacokinetics of this compound are dramatically superior to those of the 1-adamantylurea based inhibitors, like AUDA.[Cayman Chemical]
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1222780-33-7
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