| | 400827-46-5 Basic information More.. |
| Product Name: | TAK 599 | | Synonyms: | TAK 599;Ceftaroline fosaMil;PPI 0903;TAK-599 (ceftaroline fosamil);Ceftaroline Fosamil Acetate;C22H22N8O8PS4. C2H3O2;TAK-599; CEFTAROLINE FOSAMIL;TAK599; TAK 599;PPI-0903;PPI0903;PPI 0903;Ceftaroline fosamil acetate salt | | CAS: | 400827-46-5 | | MF: | C24H25N8O10PS4 | | MW: | 744.72 | | EINECS: | | | Mol File: | 400827-46-5.mol |  |
Use
Ceftaroline fosamil, also referred to as TAK-599, is a cephalosporin
antibacterial agent that was approved in the United States in October
2010 for the IV treatment of acute bacterial skin and skin structure infections
(ABSSSI) and community-acquired bacterial pneumonia (CABP).
Ceftaroline fosamil is the water-soluble, N-phosphono prodrug of ceftaroline
(T-91825), a broad-spectrum, bactericidal agent with potent activity
against methicillin-resistant Staphylococcus aureus (MRSA) strains, multidrug
resistant S. pneumonia, and common gram-negative organisms.
Ceftaroline binds to PBP2a as well as other PBPs with high
affinity and, as a result, retains potent activity. Ceftaroline exhibits activity
against most gram-positive pathogens, including β-lactam-susceptible
and -resistant S. aureus, vancomycin-resistant S. aureus, and resistant and
susceptible forms of S. pneumoniae but has weak activity against Enterococcus
sp. The gram-negative antibacterial activity of ceftaroline is limited mainly
to respiratory pathogens such as Moraxella catarrhalis and Haemophilus influenzae.
- Ceftaroline fosamil
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- US $54.00-213.00 / mg
- 2025-06-21
- CAS:400827-46-5
- Min. Order:
- Purity: ≥98%
- Supply Ability: 10g
- TAK 599
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- US $7.00 / kg
- 2019-07-06
- CAS: 400827-46-5
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 100kg
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400827-46-5
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