| | 1417162-36-7 Basic information More.. |
| Product Name: | RI-2 | | Synonyms: | RI-2;1-(3,4-Dichlorophenyl)-3-(4-methoxyphenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 1-(3,4-dichlorophenyl)-3-(4-methoxyphenyl)-4-(4-morpholinyl)-;RI2;RI 2;CS-1675;Inhibitor,RI 2,RAD51,inhibit,RI2,RI-2 | | CAS: | 1417162-36-7 | | MF: | C21H18Cl2N2O4 | | MW: | 433.28 | | EINECS: | | | Mol File: | 1417162-36-7.mol |  |
Use
RI-2 is a reversible inhibitor of RAD51 (IC50 = 44.2 μM), a protein that is central to the homologous recombination process initiated upon DNA double-strand breaks and is often overexpressed in a wide range of human cancer cell types. At 150 μM, it has been shown to inhibit DNA repair and to sensitize cancer cells to cross-linking chemotherapy in vitro.[Cayman Chemical]
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1417162-36-7
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