Fluphenazine-N-2-chloroethane (hydrochloride)

Use

Fluphenazine is a traditional antipsychotic compound that tightly binds the dopamine D2 receptor (Ki = 0.55 nM) and also reversibly inhibits calmodulin at micromolar concentrations. Fluphenazine-N-2-chloroethane (hydrochloride) is a derivative of fluphenazine that contains an alkylating chlorethylamine chain, which produces irreversible protein binding. It is a relatively selective, irreversible antagonist of D2 receptors both in vitro (IC50 = 100 nM) and in vivo, inactivating approximately 90% of D2 receptors in mice within 4 hours of treatment. Through this action, fluphenazine-B-2-chloroethane can be used to induce catalepsy in mice. It irreversibly inhibits calmodulin at higher doses (IC50 = 10 μM), which can sensitize cancer cells to TRAIL-induced apoptosis.[Cayman Chemical]

Fluphenazine-N-2-chloroethane (hydrochloride) manufacturers

• Fluphenazine-N-2-chloroethane (hydrochloride)
• 
• US $78.00-250.00 / mg
• 2024-10-28
• CAS:3892-78-2
• Min. Order:
• Purity:
• Supply Ability: 10g