Chloramphenicol sodium succinate
| | 982-57-0 Basic information More.. |
| Product Name: | Chloramphenicol sodium succinate | | Synonyms: | CHLORAMPHENICOL ALPHA-SUCCINATE SODIUM SALT;CHLORAMPHENICOL SODIUM SUCCINATE;CHLORAMPHENICOL SUCCINATE SODIUM;CHLORAMPHENICOL SUCCINATE SODIUM SALT;alpha-esterwithsodiumsuccinate;chloramphenicolmonosuccinatesodiumsalt;chloramphenicolsodiummonosuccinate;chloramphenicolsuccinatesodium*minimum80%(hpl | | CAS: | 982-57-0 | | MF: | C15H15Cl2N2O8.Na | | MW: | 445.19 | | EINECS: | 213-568-1 | | Mol File: | 982-57-0.mol |  |
Use
Chloramphenicol sodium succinate is the water-solublesodium salt of the hemisuccinate ester of chloramphenicol.Because of the low solubility of chloramphenicol, the sodiumsuccinate is preferred for intravenous administration. Theavailability of chloramphenicol from the ester followingintravenous administration is estimated to be 70% to 75%; theremainder is excreted unchanged. Poor availability ofthe active form from the ester following intramuscular injectionprecludes attaining effective plasma levels of the antibioticby this route. Orally administered chloramphenicol orits palmitate ester actually gives higher plasma levels of theactive antibiotic than does intravenously administered chloramphenicolsodium succinate. Nonetheless, effectiveconcentrations are achieved by either route.
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982-57-0
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