| 100648-29-1 Basic information More.. |
Product Name: | 11-DEOXY-11-METHYLENE PROSTAGLANDIN D2 | Synonyms: | 9ALPHA,15S-DIHYDROXY-11-METHYLENE-PROSTA-5Z,13E-DIEN-1-OIC ACID;11-deoxy-11-methylene Prostaglandin D2;11-DEOXY-11-METHYLENE PROSTAGLANDIN D2;ROZAFJXVUNORLT-SFIVEXQWSA-N;Prosta-5,13-dien-1-oic acid, 9,15-dihydroxy-11-methylene-, (5Z,9α,13E,15S)-;Prosta-5,13-dien-1-oic acid, 9,15-dihydroxy-11-methylene-, (5Z,9α,13E,15S)-;Prosta-5,13-dien-1-oicacid,9,15-dihydroxy-11-methylene-,(5z,9a,13e,15s)- | CAS: | 100648-29-1 | MF: | C21H34O4 | MW: | 350.49 | EINECS: | | Mol File: | 100648-29-1.mol | |
Use
Prostaglandin D2 (PGD2; ) is one of the five primary enzymatic prostaglandins derived directly from PGH2 . PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, leukocyte-type PGD synthase. 11-deoxy-11-methylene PGD2 is a novel, chemically stable, isosteric analog of PGD2 wherein the 11-keto group is replaced by an exocyclic methylene. In the PGE series, the analogous modification leads to a stable, somewhat less potent agonist which embodies the same uterine stimulant and cervical ripening activities as the parent prostaglandin. However, 11-deoxy-11-methylene PGD2 has been reported by one group to be essentially without agonist activity on human platelets, a DP1 receptor assay.
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100648-29-1
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