110117-83-4 Basic information More..
Product Name:1-METHYL-D-TRYPTOPHAN
Synonyms:1-METHYL-D-TRYPTOPHAN;1-Methyl-D-tryptophane;1-METHYL-D-TRYPTOPHAN 95%;(R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid;IndoxiMod;Indoximod (NLG-8189);NLG-8189;1-Me-D-Trp
CAS:110117-83-4
MF:C12H14N2O2
MW:218.25
EINECS:
Mol File:110117-83-4.mol
110117-83-4

Use

Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD+ via the kynurenine pathway. The overexpression of IDO in tumors and tumor-draining lymph nodes induces immune tolerance and enhances tumor growth in vivo. 1-methyl-D-Tryptophan is an inhibitor of IDO (IC50 = 7 μM) that is effective in vivo. In mice, 1-methyl-D-tryptophan prevents T-cell anergy triggered by dendritic cells overexpressing IDO. It augments the antitumor and antiviral immunoresponse of CD8+ T-cells and reduces tumor volume in mice with xenografts overexpressing IDO. 1-methyl-D-Tryptophan, in combination with chemotherapy, causes regression of tumors and prolongs survival. Surprisingly, 1-methyl-D-tryptophan induces the expression of IDO in human ovarian carcinoma SKOV3 cells in culture.

1-METHYL-D-TRYPTOPHAN manufacturers

  • Indoximod
  • US $64.00 / mg
  • 2024-11-07
  • CAS:110117-83-4
  • Min. Order:
  • Purity: 99.5%
  • Supply Ability: 10g
  • 1-Methyl-D-tryptophan
  • US $0.00 / Kg/Drum
  • 2024-11-04
  • CAS:110117-83-4
  • Min. Order: 1KG
  • Purity: 98%min
  • Supply Ability: 500kg
  • 1-Methyl-D-tryptophan 95%
  • US $15.00-10.00 / KG
  • 2021-07-02
  • CAS:110117-83-4
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
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