| | 1742-95-6 Basic information More.. |
| Product Name: | 4-AMINO-1,8-NAPHTHALIMIDE | | Synonyms: | 4-Amino-1,8-naphthalenedicarbimide;4-Amino-1,8-naphthalenedicarboximide;4-Aminonaphthalene-1,8-dicarbimide;6-Amino-2,3-dihydro-1H-benzo[de]isoquinoline-1,3-dione;6-Amino-2H-benzo[de]isoquinoline-1,3-dione;4-Amino-1,8-naphthalimide,98%;6-amino-1h-benz(de)isoquinoline-3(2h)-dione;6-amino-1h-benz[de]isoquinoline-3(2h)-dione | | CAS: | 1742-95-6 | | MF: | C12H8N2O2 | | MW: | 212.2 | | EINECS: | 217-110-1 | | Mol File: | 1742-95-6.mol |  |
Use
The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. 4-amino-1,8-Naphthalimide (4-ANI) is an inhibitor of PARP (IC50 = 180 nM). It blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation, although it is not cytotoxic in the absence of radiation. 4-ANI is used to study the role of PARP activity in various cell systems.
|
|
1742-95-6
Recommend Suppliers |
|