| | 170105-16-5 Basic information More.. |
| Product Name: | Imidafenacin | | Synonyms: | ONO 8025;Staybla;Uritos;1H-IMidazole-1-butanaMide,2-Methyl-a,a-diphenyl-;IMidafenacin DISCONTINUED-PATENTED PRODUCT;4-(2-METHYL-1H-IMIDAZOL-1-YL)-2,2-DIPHENYLBUTANAMIDE;2-Methyl-α,α-diphenyl-1H-iMidazole-1-butanaMide;4-(2-Methyl-1-iMidazolyl)-2,2-
diphenylbutanaMide | | CAS: | 170105-16-5 | | MF: | C20H21N3O | | MW: | 319.4 | | EINECS: | 689-703-7 | | Mol File: | 170105-16-5.mol |  |
Use
Imidafenacin, an M3/M1 muscarinic receptor antagonist, was introduced in
Japan for the oral treatment of OAB. The majority of OAB symptoms are
thought to result from overactivity of the detrusor muscle, which is primarily
mediated by acetylcholine-induced stimulation of muscarinic M3 receptors in the
bladder. Previously marketed muscarinic antagonists for OAB include propiverine,
tolterodine, oxybutynin, trospium, darifenacin, and solifenacin. In vitro,
imidafenacin is equally active against M1 and M3 receptors (Kb＝0.32 and
0.55nM, respectively), and approximately 10-fold less active against M2 receptors
(Kb＝4.13nM). Imidafenacin is chemically synthesized in three steps starting with alkylation of diphenylacetonitrile with dibromoethane, followed by condensation with 2-methylimidazole, and hydrolysis of the cyano group to a carboxamide group with 70% sulfuric acid.
- Imidafenacin
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- US $20.00 / kg
- 2024-06-26
- CAS:170105-16-5
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 2000kg
- Imidafenacin
-
- US $10.00 / kg
- 2024-06-07
- CAS:170105-16-5
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20ton
- Imidafenacin
-
- US $0.10-0.30 / kg
- 2024-05-10
- CAS:170105-16-5
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20 tons
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170105-16-5
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