| 843663-66-1 Basic information More.. |
Product Name: | TMC-207 | Synonyms: | TMC-207;R 207910;Bedaquiline(R 207910,TMC 207);Bedaquiline (TMC-207);(αS,βR)-Bedaquiline;bedaquinline;(1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(methylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol;Bedaquiline D6 | CAS: | 843663-66-1 | MF: | C32H31BrN2O2 | MW: | 555.5 | EINECS: | 1308068-626-2 | Mol File: | 843663-66-1.mol | ![843663-66-1](/CAS/GIF/843663-66-1.gif) |
Use
Bedaquiline (also known as TMC207 and R207910) is a diarylquinoline that was discovered from a high-throughput, whole-cell screening strategy with Mycobacterium smegmatis used as a surrogate for M. tuberculosis. Bedaquiline is a single enantiomer of an initial screening hit. Bedaquiline has potent and selective activity against mycobacteria, and is active against both drug-sensitive and drug-resistant M. tuberculosis. The mechanism of action of bedaquiline is unique amongst anti-TB drugs and involves inhibition of mycobacterial ATP synthase; it is not active against human ATP synthase. Bedaquiline has in vivo activity in numerous preclinical models of TB infection, alone and in combination with other anti-TB agents, and has bactericidal activity in established TB infection models.
- Bedaquiline
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- US $0.00 / g
- 2024-08-30
- CAS:843663-66-1
- Min. Order: 1g
- Purity: 99%min HPLC
- Supply Ability: 100G
- Bedaquiline
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- US $0.00-0.00 / mg
- 2024-08-28
- CAS:843663-66-1
- Min. Order: 10mg
- Purity: 0.98
- Supply Ability: 10g
- TMC-207
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- US $32.00-1.30 / KG
- 2024-04-15
- CAS:843663-66-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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843663-66-1
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