| 158792-24-6 Basic information More.. |
Product Name: | COLLISMYCIN A | Synonyms: | COLLISMYCIN A;Collismycin;(E)-4-Methoxy-5-(methylthio)-[2,2'-bipyridine]-6-carbaldehyde oxime;[2,2'-Bipyridine]-6-carboxaldehyde, 4-methoxy-5-(methylthio)-, oxime, [C(E)]-;collisiomycin | CAS: | 158792-24-6 | MF: | C13H13N3O2S | MW: | 275.33 | EINECS: | | Mol File: | 158792-24-6.mol | |
Use
Collismycin is a rare and unusual antibiotic belonging to the caerulomycin class, containing a core 2,2’-bispyridyl with an oxime substituent, produced by a strain of Streptomyces and discovered by researchers from Kirin, Japan in 1994. Collismycin was discovered as a potent inhibitor of glucocorticoid receptor binding. Collismycin has weak to moderate activity against bacteria, fungi and tumor cell lines. More recently, collismycin has been found to be a potent and selective neuroprotective agent against oxidative stress. Other recent publications have focused on the biosynthesis of collismycin as a route to the production of related analogues.
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158792-24-6
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